INT120851

Context Info Confidence 0.04 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.05 Pain Relevance 0.62

signal transduction (NFKB1, TNF) nucleoplasm (NFKB1) mitochondrion (NFKB1) intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)

Anatomy Link Frequency adipocytes 2 NFKB1 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 23 96.56 cytokine 6 85.64 anesthesia 3 76.60 Kinase C inhibitor 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Obesity 68 99.32 INFLAMMATION 21 96.56 Necrosis 3 79.76 Cancer 3 79.40 Congenital Anomalies 2 64.76 Overweight 1 52.96 Diabetes Mellitus 2 47.12 Metabolic Syndrome 2 45.24 Insulin Resistance 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.

NFkappaB Positive_regulation (promote) of Localization (secretion) of TNF-alpha

1) Confidence 0.04 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.48 Pain Relevance 0.25

However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.

nuclear factor-kappaB Positive_regulation (promote) of Localization (secretion) of TNF-alpha

2) Confidence 0.03 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.48 Pain Relevance 0.25

In the first part of this study, we identified the TLR4 signalling pathways activated by LPS (NFkappaB and p38 MAP Kinase), which lead to the secretion of TNFalpha by mature human adipocytes.

NFkappaB Positive_regulation (lead) of Localization (secretion) of TNFalpha in adipocytes associated with obesity

3) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 1.09 Pain Relevance 0.12

General Comments

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