INT120854

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (IRF1) intracellular (TNF) extracellular matrix organization (TNF)
cytosol (IRF1) extracellular space (TNF) signal transduction (TNF)
IRF1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 96.56 Very High Very High Very High
cytokine 4 84.16 Quite High
anesthesia 2 75.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 96.56 Very High Very High Very High
Necrosis 2 78.28 Quite High
Cancer 2 77.92 Quite High
Congenital Anomalies 2 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
IRF-1 Positive_regulation (promote) of Localization (secretion) of TNF-alpha
1) Confidence 0.20 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.47 Pain Relevance 0.24
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
interferon regulatory factor-1 Positive_regulation (promote) of Localization (secretion) of TNF-alpha
2) Confidence 0.20 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.47 Pain Relevance 0.24

General Comments

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