INT120857

Context Info Confidence 0.71 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 11 Disease Relevance 2.33 Pain Relevance 1.93

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1) molecular_function (Col1a1) cytoplasm (Col1a1)

Anatomy Link Frequency osteoblasts 1 connective tissue 1 osteocytes 1 Col1a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 21 97.76 Snapping jaw 6 97.52 fibrosis 133 96.16 Action potential 9 88.96 Chronic pancreatitis 3 85.84 anesthesia 8 83.40 cytokine 20 25.44 medulla 2 12.56 Inflammation 55 5.00 action potential duration 6 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 77 99.84 Renal Disease 22 97.72 Temporomandibular Joint Syndrome 6 97.52 Cirrhosis 3 96.16 Fibrosis 127 95.20 Stress 27 84.12 Pulmonary Fibrosis 29 80.16 Diabetic Cardiomyopathies 13 75.76 Disease Progression 3 61.60 Increased Venous Pressure Under Development 4 60.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The localization of type I collagen and decorin was performed by immunostaining to examine compositional change.

Localization (localization) of type I collagen

1) Confidence 0.71 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17765198 Disease Relevance 0.43 Pain Relevance 0.43

The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.

Localization (localized) of type I collagen in osteocytes associated with metalloproteinase

2) Confidence 0.66 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36

Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.

Localization (localization) of type I collagen

3) Confidence 0.62 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31

Type I collagen and transforming growth factor-beta1 secretion was evaluated by ELISA, and matrix metalloproteinase activity was assessed by gelatin zymography.

Localization (secretion) of Type I collagen

4) Confidence 0.48 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17764527 Disease Relevance 0 Pain Relevance 0

Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.

Localization (secretion) of collagen type I mRNA

5) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0 Pain Relevance 0.13

The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.

Localization (localized) of type I collagen in osteoblasts associated with metalloproteinase

6) Confidence 0.22 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36

Immunohistochemistry of LV free wall showed that type I collagen was increased in diabetic rats (diabetic 7.1 ± 0.1%, control 12.7 ± 0.1%; P < 0.01), and F-actin content reduced (diabetic 56.9 ± 0.6%; control 61.7 ± 0.4%; P < 0.0001) with a disrupted structure.

Localization (increased) of type I collagen associated with diabetes mellitus

7) Confidence 0.22 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.01 Pain Relevance 0.08

It has also been shown that HSP47 typically colocalized with type I collagen in these models.

Localization (colocalized) of type I collagen

8) Confidence 0.22 Published 2007 Journal Respir Res Section Body Doc Link PMC1876458 Disease Relevance 0.77 Pain Relevance 0.26

Localization of type I collagen (diluted 1?

Localization (Localization) of type I collagen

9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0 Pain Relevance 0

; Collagen type I (sense) 5?

Localization (sense) of Collagen type I

10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0 Pain Relevance 0

Knowing that one PINP molecule is released per collagen type I molecule that is deposited in the connective tissue, it is evident that the LSEC must have a high capacity to eliminate these collagenous molecules effectively from the circulation.

Localization (released) of collagen type I molecule in connective tissue

11) Confidence 0.06 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.11 Pain Relevance 0

General Comments

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