INT120858

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.46
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
PSCs 8
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 98.04 Very High Very High Very High
Inflammation 4 90.24 High High
cINOD 4 88.64 High High
fibrosis 10 82.24 Quite High
Chronic pancreatitis 10 81.28 Quite High
Disease Link Frequency Relevance Heat
Fracture Healing 12 99.08 Very High Very High Very High
INFLAMMATION 4 90.64 High High
Pancreatitis 10 74.96 Quite High
Stress 4 74.80 Quite High
Fibrosis 12 73.96 Quite High
Tibia Fractures 2 66.24 Quite High
Primary Sclerosing Cholangitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local and systemic release of transforming growth factor beta 1 (TGF-beta1) is known to increase during the process of fracture healing and this cytokine stimulates bone healing.
Positive_regulation (increase) of Localization (release) of TGF-beta1 associated with fracture healing and cytokine
1) Confidence 0.68 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.48 Pain Relevance 0.26
Local and systemic release of transforming growth factor beta 1 (TGF-beta1) is known to increase during the process of fracture healing and this cytokine stimulates bone healing.
Positive_regulation (increase) of Localization (release) of transforming growth factor beta 1 associated with fracture healing and cytokine
2) Confidence 0.49 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.48 Pain Relevance 0.26
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Positive_regulation (promoted) of Localization (secretion) of TGF-beta1
3) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.05 Pain Relevance 0.17
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Positive_regulation (activated) of Localization (secretion) of TGF-beta1
4) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0 Pain Relevance 0.12
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Positive_regulation (activated) of Localization (secreted) of transforming growth factor-beta1 in PSCs
5) Confidence 0.15 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Positive_regulation (activated) of Localization (secreted) of TGF-beta1 in PSCs
6) Confidence 0.15 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
EGCG also suppressed ethanol-induced p38 mitogen-activated protein (MAP) kinase phosphorylation, alpha-smooth muscle actin production in PSCs and activated transforming growth factor-beta1 secretion into the medium.
Positive_regulation (activated) of Localization (secretion) of transforming growth factor-beta1 in PSCs
7) Confidence 0.07 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0
EGCG also suppressed ethanol-induced p38 mitogen-activated protein (MAP) kinase phosphorylation, alpha-smooth muscle actin production in PSCs and activated transforming growth factor-beta1 secretion into the medium.
Positive_regulation (ethanol-induced) of Localization (secretion) of transforming growth factor-beta1 in PSCs
8) Confidence 0.05 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

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