INT12086

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.65
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
Morphine 16 100.00 Very High Very High Very High
narcan 2 99.04 Very High Very High Very High
metalloproteinase 6 98.62 Very High Very High Very High
antagonist 46 94.48 High High
opiate 2 80.08 Quite High
chemokine 6 74.44 Quite High
Endocannabinoid 48 71.68 Quite High
Cannabinoid 52 61.96 Quite High
Cannabinoid receptor 36 57.00 Quite High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 88 100.00 Very High Very High Very High
Intervertebral Disk Degeneration 4 98.96 Very High Very High Very High
Apoptosis 25 96.96 Very High Very High Very High
Necrosis 8 94.68 High High
Cancer 2 94.32 High High
Death 5 89.60 High High
Cytomegalovirus Infection 1 79.12 Quite High
Infection 1 78.72 Quite High
INFLAMMATION 28 50.00 Quite Low
Fibrosis 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (1 pM and 10 nM) alone did not significantly modulate the release of TGF-beta, IL-6 or TNF-alpha.
Neg (not) Regulation (modulate) of Localization (release) of TGF-beta associated with morphine
1) Confidence 0.43 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.19 Pain Relevance 0.69
g/L, This range is very important in the future therapeutic applications of the TGF-?
Regulation (important) of Localization (applications) of TGF
2) Confidence 0.38 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.26 Pain Relevance 0
To assess the effects of WIN treatment of PSC on the secretion of cytokines IL-6, MCP-1 and TGFbeta, cell culture supernatants were subjected to ELISA.
Regulation (effects) of Localization (secretion) of TGFbeta associated with primary sclerosing cholangitis and cytokine
3) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.63 Pain Relevance 0.34
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
Neg (neither) Regulation (altered) of Neg (neither) Localization (secreted) of TGFbeta associated with metalloproteinase and cytokine
4) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.43 Pain Relevance 0.24
The amplifying effect of morphine on the release of TGF-beta was mediated through a naloxone-sensitive mechanism.
Regulation (effect) of Localization (release) of TGF-beta associated with narcan and morphine
5) Confidence 0.26 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.15 Pain Relevance 0.82

General Comments

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