INT12087

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 8
Speculated 4
Reported most in Body
Documents 44
Total Number 48
Disease Relevance 28.71
Pain Relevance 15.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
blood 6
monocytes 6
lung 5
Macrophages 4
microglia 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 560 100.00 Very High Very High Very High
cytokine 260 100.00 Very High Very High Very High
cINOD 46 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
gABA 17 99.98 Very High Very High Very High
rheumatoid arthritis 398 99.84 Very High Very High Very High
IPN 4 99.80 Very High Very High Very High
dexamethasone 13 99.34 Very High Very High Very High
aspirin 50 99.28 Very High Very High Very High
Infliximab 113 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 665 100.00 Very High Very High Very High
Cancer 136 100.00 Very High Very High Very High
Pulmonary Disease 74 100.00 Very High Very High Very High
Necrosis 71 100.00 Very High Very High Very High
Rheumatoid Arthritis 475 99.84 Very High Very High Very High
Injury 49 99.78 Very High Very High Very High
Systemic Lupus Erythematosus 94 99.60 Very High Very High Very High
Hypersensitivity 6 99.40 Very High Very High Very High
Cirrhosis 25 98.76 Very High Very High Very High
Diabetes Mellitus 82 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we investigated the effect of morphine on the release of tumor necrosis factor (TNF)-alpha from murine neonatal microglia.
Spec (investigated) Regulation (effect) of Localization (release) of TNF in microglia associated with necrosis, cancer and morphine
1) Confidence 0.62 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.42 Pain Relevance 0.70
The combinatory effects of the drugs on the release of TNF-alpha after lipopolysaccharide stimulation were analyzed.
Regulation (effects) of Localization (release) of TNF-alpha
2) Confidence 0.58 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.73 Pain Relevance 0.28
We investigated the ability of dexamethasone, indomethacin, and rofecoxib to modulate nuclear factor-kappaB (NF-kappaB) activation and TNF-alpha release from human monocytes challenged with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA).
Regulation (modulate) of Localization (release) of TNF-alpha in monocytes associated with dexamethasone
3) Confidence 0.56 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.38
The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay.
Regulation (effects) of Localization (release) of TNF-alpha in blood associated with inflammation
4) Confidence 0.50 Published 1993 Journal Agents Actions Section Title Doc Link 8273590 Disease Relevance 0.19 Pain Relevance 0.22
For example, although inhibition of PDE7A with BRL 50481 does not itself affect T cell proliferation or TNF-?
Neg (not) Regulation (affect) of Localization (proliferation) of TNF in T cell
5) Confidence 0.44 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.52 Pain Relevance 0.11
They inferred that IL-6 release probably occurred through a route independent of the release of TNF-?
Neg (independent) Regulation (independent) of Localization (release) of TNF
6) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.34 Pain Relevance 0.17
NO and aspirin have both been previously shown to influence the release of TNF?
Regulation (influence) of Localization (release) of TNF associated with aspirin
7) Confidence 0.44 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.50 Pain Relevance 0.42
It has been shown that thalidomide has important immunomodulatory effects in that it decreases TNF-?
Regulation (effects) of Localization (decreases) of TNF
8) Confidence 0.44 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.60 Pain Relevance 0
Inflammatory cells, through the secretion of stimulatory factors such as VEGF-C and TNF-?
Regulation (through) of Localization (secretion) of TNF associated with inflammation
9) Confidence 0.44 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 2.00 Pain Relevance 0.33
R,R-Glycopyrrolate alone did not affect LPS induced TNF-alpha release.
Neg (not) Regulation (affect) of Localization (release) of TNF-alpha
10) Confidence 0.42 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.69 Pain Relevance 0.27
METHODS: We examined the influence of gammalinolenic acid added to cells in vitro and administered orally in vivo on interleukin-1 beta and tumor necrosis factor-alpha secretion from activated human peripheral blood monocytes.
Spec (examined) Regulation (influence) of Localization (secretion) of tumor necrosis factor-alpha in monocytes
11) Confidence 0.42 Published 1999 Journal J. Investig. Med. Section Body Doc Link 10361385 Disease Relevance 0.38 Pain Relevance 0
Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo.
Regulation (Effects) of Localization (secretion) of tumor necrosis factor-alpha in monocytes associated with necrosis and cancer
12) Confidence 0.42 Published 1999 Journal J. Investig. Med. Section Title Doc Link 10361385 Disease Relevance 0.66 Pain Relevance 0.27
Morphine (1 pM and 10 nM) alone did not significantly modulate the release of TGF-beta, IL-6 or TNF-alpha.
Neg (not) Regulation (modulate) of Localization (release) of TNF-alpha associated with morphine
13) Confidence 0.41 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.19 Pain Relevance 0.69
Morphine did not alter the release of immunodetectable IL-6 or TNF-alpha from stimulated cells.
Neg (not) Regulation (alter) of Localization (release) of TNF-alpha associated with morphine
14) Confidence 0.41 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.16 Pain Relevance 0.82
Heparinized human whole blood was evaluated as a model to study the effects of various classes of anti-inflammatory drugs on IL-1 beta and TNF-alpha release from leukocytes.
Regulation (effects) of Localization (release) of TNF-alpha in blood associated with inflammation and cinod
15) Confidence 0.37 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273590 Disease Relevance 0.17 Pain Relevance 0.21
One can then postulate that this particular induction is due to the partial blockage of TNF-?
Spec (partial) Regulation (due) of Spec (partial) Localization (blockage) of TNF
16) Confidence 0.28 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.96 Pain Relevance 0.74
As a control for the presence of Th1 or TNF?
Regulation (control) of Localization (presence) of TNF
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.51 Pain Relevance 0.26
Besides neutrophils, lung macrophages are believed to play an important role in COPD, in part by their ability to release TNF-?
Regulation (role) of Localization (release) of TNF in lung associated with pulmonary disease
18) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.38 Pain Relevance 0.11
Results indicated an involvement of antimalarial treatment in the amount of serum TNF?
Regulation (involvement) of Localization (amount) of TNF
19) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.35 Pain Relevance 0.07
However, it is unclear whether this is due to biological superiority of TNF-?
Spec (whether) Regulation (due) of Localization (superiority) of TNF
20) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 1.35 Pain Relevance 0.70

General Comments

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