INT120874

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.47
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
pancreas 1
goblet cells 1
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 113 100.00 Very High Very High Very High
Cannabinoid 94 100.00 Very High Very High Very High
Pain 24 100.00 Very High Very High Very High
Analgesic 8 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
antagonist 45 99.96 Very High Very High Very High
Chronic pancreatitis 31 98.20 Very High Very High Very High
analgesia 3 94.12 High High
cannabis 6 87.44 High High
Cannabinoid receptor 55 84.68 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 32 98.20 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.64 Very High Very High Very High
Pain 18 97.48 Very High Very High Very High
Colitis 20 95.44 Very High Very High Very High
Primary Sclerosing Cholangitis 44 95.28 Very High Very High Very High
Cognitive Disorder 2 95.12 Very High Very High Very High
Metaplasia 1 85.20 High High
Inflammatory Bowel Disease 54 85.04 High High
Cardiovascular Disease 1 75.00 Quite High
Disease 34 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, the endocannabinoid system, including the CB1 and CB2 receptors, the metabolizing enzyme fatty acid amide hydrolase and the anandamide transporter, is a potential target for the development of novel therapeutic drugs in the treatment of various conditions, such as pain, feeding disorders and vascular disease among others.
Regulation (target) of CB2 associated with pain, endocannabinoid and increased venous pressure under development
1) Confidence 0.44 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320476 Disease Relevance 0.63 Pain Relevance 0.62
Although the CB2 receptor antagonist SR144528 (1 ?
Regulation (Although) of CB2 receptor associated with antagonist
2) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.11 Pain Relevance 0.36
There was no change in CB2 immunoreactivity between quiescent and control samples.
Neg (no) Regulation (change) of CB2
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.70 Pain Relevance 0
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain.
Regulation (Targeting) of CB2 associated with pain, endocannabinoid and analgesic
4) Confidence 0.26 Published 2009 Journal Brain research reviews Section Title Doc Link 19150370 Disease Relevance 0.42 Pain Relevance 1.94
CB2 is not involved in Echinacea-induced [Ca2+]i increase in HEK293 cells
Neg (not) Regulation (involved) of CB2
5) Confidence 0.23 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.10
CB2 immunoreactivity was detected in the colonic epithelium of both absorptive and goblet cells (fig. 2H).
Regulation (immunoreactivity) of CB2 in goblet cells
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.05 Pain Relevance 0.03
Regulation of CB1, CB2 and endocannabinoids in normal pancreas and chronic pancreatitis
Regulation (Regulation) of CB2 in pancreas associated with endocannabinoid and chronic pancreatitis
7) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.55 Pain Relevance 0.33

General Comments

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