INT12089

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.92
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSX2) transcription factor binding (MSX2) cytoplasm (MSX2)
MSX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 1 98.40 Very High Very High Very High
depression 1 93.44 High High
Pain 5 86.36 High High
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Incontinence 33 100.00 Very High Very High Very High
Endometrial Cancer 153 99.32 Very High Very High Very High
Pain 2 98.40 Very High Very High Very High
Anxiety Disorder 1 93.88 High High
Depression 1 93.44 High High
Overactive Bladder 1 83.68 Quite High
Congenital Anomalies 3 76.40 Quite High
Apoptosis 16 75.76 Quite High
Syndrome 25 75.00 Quite High
Incontinence 1 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients evidence poor control over testing and relaxing PFM, elevations of PFM activity under various conditions, and chronic pain as a prominent symptom.
Positive_regulation (elevations) of PFM associated with lasting pain
1) Confidence 0.46 Published 1992 Journal J Behav Med Section Abstract Doc Link 1625341 Disease Relevance 0.87 Pain Relevance 0.22
The difference did not differ significantly during maximal electric stimulation of the PFM and during maximal electric stimulation and voluntary contraction of the PFM.
Positive_regulation (stimulation) of PFM associated with stress incontinence
2) Confidence 0.36 Published 1998 Journal Ceska Gynekol Section Abstract Doc Link 9750376 Disease Relevance 0.88 Pain Relevance 0.08
During contraction caused by maximal electric stimulation of the PFM and at rest this difference was 21.3.
Positive_regulation (stimulation) of PFM associated with stress incontinence
3) Confidence 0.36 Published 1998 Journal Ceska Gynekol Section Abstract Doc Link 9750376 Disease Relevance 0.89 Pain Relevance 0.09
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Positive_regulation (regulated) of MSX2 associated with endometrial cancer
4) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.29 Pain Relevance 0

General Comments

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