INT120895

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 15.86
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 8
blood 1
skeletal muscle 1
plaque 1
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 155 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
depression 59 99.80 Very High Very High Very High
cytokine 66 99.36 Very High Very High Very High
chemokine 83 99.24 Very High Very High Very High
noradrenaline 2 99.12 Very High Very High Very High
Lasting pain 2 99.08 Very High Very High Very High
Chronic pancreatitis 18 98.04 Very High Very High Very High
Fibrositis 101 97.84 Very High Very High Very High
endometriosis 7 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 201 100.00 Very High Very High Very High
Insulin Resistance 24 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 100.00 Very High Very High Very High
Shock 2 100.00 Very High Very High Very High
Depression 61 99.80 Very High Very High Very High
Toxicity 8 99.76 Very High Very High Very High
Syndrome 16 99.44 Very High Very High Very High
Pancreatitis 20 99.12 Very High Very High Very High
Renal Disease 69 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MCP-1 has been
MCP-1 Binding (been) of
1) Confidence 0.37 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.22 Pain Relevance 0
The release of monocyte chemoattractant protein-1 (MCP-1, also known as CCL2), in particular, is potentiated by opiate-HIV Tat interactions in vitro.
MCP-1 Binding (interactions) of in monocyte associated with acquired immune deficiency syndrome or hiv infection and opiate
2) Confidence 0.37 Published 2006 Journal Glia Section Abstract Doc Link 16206161 Disease Relevance 0.72 Pain Relevance 0.68
Macrophages recruited by monocyte chemoattractant protein-1 (MCP-1/CCL2) and activated by interferon, and proinflammatory mediators like tumour necrosis factor alpha, interferon gamma, interleukin-6 and interleukin-1beta appear to be common elements in this group of diseases.
monocyte chemoattractant protein-1 Binding (recruited) of in monocyte associated with necrosis, cancer and disease
3) Confidence 0.37 Published 2009 Journal Pharmacol. Ther. Section Abstract Doc Link 19788897 Disease Relevance 1.22 Pain Relevance 0.22
Combination of CCR1 mRNA, MCP1, and CA125 measurements in peripheral blood as a diagnostic test for endometriosis.
MCP1 Binding (Combination) of in blood associated with endometriosis
4) Confidence 0.36 Published 2008 Journal Reprod Sci Section Title Doc Link 19050323 Disease Relevance 0.54 Pain Relevance 0.33
In addition, vascular SMC pathophysiology is related to inflammation which could explain the MCP-1 QTL linkage.
MCP-1 Binding (linkage) of associated with inflammation
5) Confidence 0.26 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 1.44 Pain Relevance 0.13
Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis.
Monocyte chemotactic protein-1 Binding (associated) of in Monocyte associated with pancreatitis and shock
6) Confidence 0.26 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17940904 Disease Relevance 0.76 Pain Relevance 0.57
Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis.
MCP-1 Binding (associated) of in Monocyte associated with pancreatitis and shock
7) Confidence 0.26 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17940904 Disease Relevance 0.76 Pain Relevance 0.56
Levels of interleukin 6, interleukin 8, and monocyte chemoattractant protein 1 were higher in patients with serum alanine aminotransferase > 1000 IU/L, and monocyte chemoattractant protein 1 had the strongest association with toxicity.
monocyte chemoattractant protein 1 Binding (association) of in monocyte associated with toxicity
8) Confidence 0.22 Published 2005 Journal J Clin Pharmacol Section Abstract Doc Link 16172181 Disease Relevance 0.78 Pain Relevance 0.68
The specific interaction of MCP-1 with skeletal muscle has not been studied in detail, but we have shown that MCP-1 stimulates the release of IL-1?
MCP-1 Binding (interaction) of in skeletal muscle
9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.93 Pain Relevance 0.43
Are low total serum antioxidant status and elevated levels of C-reactive protein and monocyte chemotactic protein-1 associated with cardiac syndrome X?
monocyte chemotactic protein-1 Binding (associated) of in monocyte associated with inflammation and syndrome
10) Confidence 0.20 Published 2005 Journal Circ. J. Section Title Doc Link 16195619 Disease Relevance 0.66 Pain Relevance 0.38
2AAR-YFP/CFP to become internalized following stimulation, whereas upon activation with CCL2 CCR2 was readily detected on endosomal structures (Figure 4B).
CCL2 Binding (activation) of
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0 Pain Relevance 0.13
2AAR) display comparable signal transduction responses, such as calcium mobilization, MAP-kinase activation and chemotaxis, to the noradrenaline homlogue UK 14'304 as when stimulated with CCL2, which binds to the endogenous chemokine receptor CCR2.
CCL2 Binding (binds) of associated with chemokine and noradrenaline
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2855346 Disease Relevance 0 Pain Relevance 0.10
For example, in cells co-expressing the CCR2b and CCR5 chemokine receptors CCR5-specific ligands that are unable to compete for MCP-1 binding on cells expressing CCR2b alone, and hence presumable do not bind directly to CCR2b, were able to prevent efficiently MCP-1 binding when the two receptors were co-expressed [26].
MCP-1 Binding (binding) of associated with chemokine
13) Confidence 0.18 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.15
Comparison of simulated uMCP-1 and uP:C dynamics during flare cycle with patients data
uMCP-1 Binding (Comparison) of
14) Confidence 0.16 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2877652 Disease Relevance 0.51 Pain Relevance 0.06
For example, in cells co-expressing the CCR2b and CCR5 chemokine receptors CCR5-specific ligands that are unable to compete for MCP-1 binding on cells expressing CCR2b alone, and hence presumable do not bind directly to CCR2b, were able to prevent efficiently MCP-1 binding when the two receptors were co-expressed [26].
MCP-1 Binding (binding) of associated with chemokine
15) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.13
The development of drugs specifically targeted against IL-6 and MCP-1 may be useful in the prevention of plaque formation, myocardial infarction and restenosis.
MCP-1 Binding (targeted) of in plaque associated with cardiovascular disease and myocardial infarction
16) Confidence 0.14 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320854 Disease Relevance 1.20 Pain Relevance 0.26
Interestingly, we did not find an association between MCP-1 and depression as previously reported [28].
MCP-1 Neg (not) Binding (association) of associated with depression
17) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766003 Disease Relevance 1.52 Pain Relevance 0.60
Carotid IMT and all arterial elastic parameters calculated in this study were not found to be associated with serum levels of TNF-alpha, IL-6, and MCP-1.
MCP-1 Binding (associated) of
18) Confidence 0.12 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18487068 Disease Relevance 0.05 Pain Relevance 0
Elevated MCP-1 has been shown to be associated with depression [24], chronic pain diagnosis such as fibromyalgia [25] and chronic inflammatory diseases such as rheumatic arthritis [26].
MCP-1 Binding (associated) of associated with inflammation, depression, lasting pain, disease, fibrositis and arthritis
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766003 Disease Relevance 1.48 Pain Relevance 0.64
= 0.18, P < 0.01) and MCP-1 for ED-FMD (?
MCP-1 Binding (0.18) of
20) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.73 Pain Relevance 0.20

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