INT1209

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Context Info
Confidence 0.37
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.72
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kitl) extracellular region (Kitl) cell adhesion (Kitl)
plasma membrane (Kitl) cytoskeleton (Kitl) cytoplasm (Kitl)
Anatomy Link Frequency
SH2 1
macrophage 1
fibroblast 1
nucleus 1
nucleus accumbens 1
Kitl (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 27 100.00 Very High Very High Very High
Nucleus accumbens 4 99.92 Very High Very High Very High
Raphe magnus 9 99.76 Very High Very High Very High
Pain 38 99.62 Very High Very High Very High
narcan 8 99.62 Very High Very High Very High
mu opioid receptor 1 99.44 Very High Very High Very High
antinociception 2 98.56 Very High Very High Very High
local anesthetic 2 98.20 Very High Very High Very High
lidocaine 6 97.88 Very High Very High Very High
cytokine 221 93.84 High High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 262 100.00 Very High Very High Very High
Urological Neuroanatomy 27 100.00 Very High Very High Very High
Infection 435 99.60 Very High Very High Very High
Cold Sores 949 98.28 Very High Very High Very High
Pain 44 96.88 Very High Very High Very High
Hematological Disease 12 89.96 High High
Adhesions 43 89.68 High High
Cancer 440 89.36 High High
Necrosis 14 88.80 High High
Targeted Disruption 8 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patch formation of Con A receptors on the cell surface as revealed by fluoresceinated Con A was enhanced by these amines.
Con Binding (formation) of
1) Confidence 0.37 Published 1982 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 6808705 Disease Relevance 0 Pain Relevance 0.16
Our earlier studies have demonstrated the activation of these GTPases by KSHV infection and stimulation by interaction of the KSHV envelope glycoprotein gB with adherent endothelial or fibroblast cell integrins [25],[35],[52].
gB Binding (interaction) of in fibroblast associated with herpes simplex virus and infection
2) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.57 Pain Relevance 0
In order to study the contribution of the electronic, hydrophobic, and conformational properties of the amino acid residue at position 3 in deltorphin C on binding to delta and mu opioid receptors, a series of 5- and 6-membered ring and bicyclic amino acid replacements at position 3 were prepared by solution synthesis methods.
C on Binding (binding) of associated with mu opioid receptor
3) Confidence 0.35 Published 1993 Journal J. Med. Chem. Section Abstract Doc Link 8254604 Disease Relevance 0 Pain Relevance 0.09
Binding of radiolabeled Con A or LPS to lymphocyte membranes in the presence of lidocaine or CPZ was not inhibited.
Con Binding (Binding) of in lymphocyte associated with lidocaine
4) Confidence 0.30 Published 1976 Journal J. Immunol. Section Abstract Doc Link 176268 Disease Relevance 0 Pain Relevance 0.57
This region of the tyrosine kinase domain undergoes a conformational change after the transphosphorylation of the autoinhibitory JM domain after KITL binding.
KITL Binding (binding) of
5) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.23 Pain Relevance 0
The binding of KITL, induces the dimerization of the KIT molecule, followed by a change in the configuration of the intracellular domain and the autophosphorylation of the receptor, opening several docking sites for signal transduction molecules containing SH2 binding domains.
KITL Binding (binding) of in SH2
6) Confidence 0.26 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.18 Pain Relevance 0
Mouse and human CCRL2/L1.2 cells migrated to CXCL12 and CCL19 (via endogenously expressed CXCR4 and CCR7, respectively), and primary mouse peritoneal mast cells migrated to stem cell factor (SCF), indicating their ability to demonstrate chemotaxis is this assay (Fig. 7, C and D).
stem cell factor Binding (migrated) of in mast cells
7) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.05
Recombinant human stem cell factor (SCF), granulocyte-macrophage colony stimulating factor (GM-CSF), and TNF-?
stem cell factor Binding (Recombinant) of in macrophage
8) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.11 Pain Relevance 0.10
Upon binding to one of these entry receptors, conformational changes in gD lead to interaction with gB or gH-gL dimer, which results in membrane fusion by a mechanism not known in detail (fig. 1) [41,53].
gB Binding (interaction) of
9) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.90 Pain Relevance 0
binds to gB and functions as an entry receptor during HSV-1 infection in concert with an interaction between gD and gD receptors [3].
gB Binding (binds) of associated with cold sores and infection
10) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.64 Pain Relevance 0
Entry via this mode is initiated by interaction of viral gC and/or gB with heparan sulfate (HS), followed by interaction of gD with one of its three receptors.
gB Binding (interaction) of
11) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.66 Pain Relevance 0
Further studies on interactions between periaqueductal gray, nucleus accumbens and habenula in antinociception.
periaqueductal gray Binding (interactions) of in habenula associated with antinociception, nucleus accumbens, narcan and central grey
12) Confidence 0.00 Published 1992 Journal Brain Res. Section Title Doc Link 1504835 Disease Relevance 0.54 Pain Relevance 1.11
Further studies on interactions between periaqueductal gray, nucleus accumbens and habenula in antinociception.
periaqueductal gray Binding (interactions) of in nucleus accumbens associated with antinociception, nucleus accumbens, narcan and central grey
13) Confidence 0.00 Published 1992 Journal Brain Res. Section Title Doc Link 1504835 Disease Relevance 0.54 Pain Relevance 1.11
Interactions between the lateral hypothalamus and the periaqueductal gray.
periaqueductal gray Binding (Interactions) of in hypothalamus associated with central grey
14) Confidence 0.00 Published 1988 Journal J. Neurosci. Section Title Doc Link 2900881 Disease Relevance 0.63 Pain Relevance 0.35
The role of acetylcholine in the function of the nucleus raphe magnus and in the interaction of this nucleus with the periaqueductal gray.
periaqueductal gray Binding (interaction) of in nucleus associated with raphe magnus and central grey
15) Confidence 0.00 Published 1982 Journal Brain Res. Section Title Doc Link 7150956 Disease Relevance 0.72 Pain Relevance 0.75

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