INT120901

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 31.63
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
T cells 8
bowel 6
monocytes 4
lung 4
lymph node 2
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 647 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
COX2 9 100.00 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
spastic colon 24 99.60 Very High Very High Very High
fibrosis 317 99.36 Very High Very High Very High
rheumatoid arthritis 199 99.04 Very High Very High Very High
Inflammatory response 56 97.48 Very High Very High Very High
chemokine 141 97.20 Very High Very High Very High
Inflammation 620 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 238 100.00 Very High Very High Very High
Infection 444 99.84 Very High Very High Very High
Death 76 99.80 Very High Very High Very High
Targeted Disruption 55 99.78 Very High Very High Very High
Parasitic Infection 5 99.70 Very High Very High Very High
Respiratory Syncytial Virus 172 99.62 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

18 99.60 Very High Very High Very High
Airway Remodeling 28 99.38 Very High Very High Very High
Fibrosis 187 99.36 Very High Very High Very High
Asthma 796 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 in monocytes associated with asthma and rhinitis
1) Confidence 0.57 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 in monocytes associated with asthma and rhinitis
2) Confidence 0.41 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 associated with sprains and strains
3) Confidence 0.41 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.39 Pain Relevance 0.35
The increased levels of IL-13 mRNA and protein in the sputum of subjects with asthma have been correlated with an increased eosinophil count6 and airway hyper-responsiveness.7 It is generally agreed that many allergic disorders are associated with hypereosinophilia, including asthma and atopic dermatitis.
Positive_regulation (increased) of Gene_expression (levels) of IL-13 in eosinophil associated with asthma, hypersensitivity and eczema
4) Confidence 0.38 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.22
Transgenic mice that overexpress IL-13 develop tissue fibrosis through production and activation of TGF-?
Positive_regulation (overexpress) of Gene_expression (overexpress) of IL-13 associated with targeted disruption and fibrosis
5) Confidence 0.34 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 1.81 Pain Relevance 0.80
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 associated with sprains and strains
6) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.39 Pain Relevance 0.35
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Positive_regulation (preceded) of Gene_expression (expression) of IL-13 associated with sprains and strains
7) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.40 Pain Relevance 0.36
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 associated with sprains and strains
8) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.39 Pain Relevance 0.35
Because IgE levels in BALF are dependent upon IL-4, IL-5, IL-13 and may be considered
Positive_regulation (upon) of Gene_expression (dependent) of IL-13
9) Confidence 0.29 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.13
Experimental parasitic infection of mice bowel resulted in elevated substance P levels and increased expression of cyclooxygenase 2 (COX 2) enzyme, prostaglandin E2, IL-4, IL-5, and IL-13.
Positive_regulation (resulted) of Gene_expression (expression) of IL-13 in bowel associated with parasitic infection, cox2 and substance p
10) Confidence 0.27 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.73 Pain Relevance 0.86
are largely antagonistic, where IL-13 promotes mesenchymal cell survival and IFN-?
Positive_regulation (where) of Gene_expression (promotes) of IL-13 in mesenchymal cell
11) Confidence 0.24 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.85 Pain Relevance 0.36
This is consistent with our previous finding that allergic mice with two RSV infections had an increase in the number of cells producing IL-4 and IL-13 [1].
Positive_regulation (increase) of Gene_expression (producing) of IL-13 associated with hypersensitivity, infection and respiratory syncytial virus
12) Confidence 0.23 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 1.29 Pain Relevance 0.24
For example, pulmonary fibroblasts from IPF patients have spontaneously elevated levels of IL-13 and IL-4 receptor subunits, and it has been suggested that the abnormal proliferative properties of lung fibroblasts from certain lung fibrosis patient groups can be modulated in a manner that is dependent on the IL-4 and IL-13 receptor expression [10].
Positive_regulation (dependent) of Gene_expression (expression) of IL-13 in lung associated with fibrosis and pulmonary fibrosis
13) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.88 Pain Relevance 0.44
Prostaglandin E2 (PGE2), IL-13, vascular endothelial growth factor (VEGF) and cysteinyl leukotrienes (cysLT) were measured as potential mediators of airway hyperresponsiveness using enzyme immunoassay kits (PGE2, cysLT: Cayman Chemicals, MI, USA; IL-13, VEGF: Quantikine, R&D Systems, MN, USA) according the manufacturer's instructions.
Positive_regulation (mediators) of Gene_expression (measured) of IL-13 in PGE2
14) Confidence 0.22 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.57 Pain Relevance 0.12
Another study, demonstrated different gene expression profiles including increased expression of STAT6, IL-4, IL-13 in allergen-stimulated Th2 cells [6].
Positive_regulation (increased) of Gene_expression (expression) of IL-13 in Th2 cells
15) Confidence 0.21 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 1.11 Pain Relevance 0.08
We did not find increased levels of IL-4 or IL-13 and thus it is unclear whether this increased IL-5 is indicative of a shift towards a Th2 phenotype.
Neg (not) Positive_regulation (increased) of Gene_expression (levels) of IL-13
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.85 Pain Relevance 0.32
mice showed similar or lower cell counts in the BAL, less infiltration in the lung tissue, less mucus production, no OVA-specific IgE and lower IgG1 in the serum, and no increased production of Th2 cytokines, IL-4, IL-5, and IL-13 in the lung.
Neg (no) Positive_regulation ( no incre) of Neg (no) Gene_expression (sed produc) of IL-13 in lung associated with cytokine
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.58 Pain Relevance 0.26
Experimental parasitic infection of mice bowel resulted in elevated substance P levels and increased expression of cyclooxygenase 2 (COX 2) enzyme, prostaglandin E2, IL-4, IL-5, and IL-13.
Positive_regulation (elevated) of Gene_expression (expression) of IL-13 in bowel associated with parasitic infection, cox2 and substance p
18) Confidence 0.18 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.73 Pain Relevance 0.86
Experimental parasitic infection of mice bowel resulted in elevated substance P levels and increased expression of cyclooxygenase 2 (COX 2) enzyme, prostaglandin E2, IL-4, IL-5, and IL-13.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 in bowel associated with parasitic infection, cox2 and substance p
19) Confidence 0.18 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.73 Pain Relevance 0.86
This results in an increased expression of Th2 cytokines, such as IL-4, IL-5 and IL-13.
Positive_regulation (increased) of Gene_expression (expression) of IL-13 associated with cytokine
20) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.51 Pain Relevance 0.13

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