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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkcg, Fos) response to stress (Prkcg, Fos) cytosol (Prkcg)
aging (Fos) nucleolus (Fos) plasma membrane (Prkcg)
Anatomy Link Frequency
spinal 2
neurons 2
Prkcg (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 13 100.00 Very High Very High Very High
Endogenous opioid 1 98.24 Very High Very High Very High
Dorsal horn 8 97.84 Very High Very High Very High
narcan 12 95.28 Very High Very High Very High
spinal dorsal horn 1 95.12 Very High Very High Very High
opioid receptor 3 92.12 High High
Spinal cord 3 91.16 High High
intrathecal 2 74.88 Quite High
Pain 3 25.00 Low Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study was designed to determine whether the protein kinase C (PKC) is involved in nociceptive c-Fos expression and the concomitant signaling processes of endogenous opioid-like substances (OLS) that modulate c-Fos expression in the spinal dorsal horn following formalin injection into the unilateral hindpaw in rats by using immunocytochemical techniques.
PKC Regulation (involved) of Gene_expression (expression) of c-Fos in spinal associated with nociception, kinase c, spinal dorsal horn and endogenous opioid
1) Confidence 0.50 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16861172 Disease Relevance 0.24 Pain Relevance 0.43
These results suggest that: (1) PKC plays a role in the c-fos protein expression only in nearly one half of the Fos-LI neurons in the dorsal horn; and (2) PKC is possibly not involved in the concomitant modulation on the nociception mediated by micro- (and also partly delta-) opioid receptors in the spinal cord.
PKC Regulation (plays) of Gene_expression (expression) of c-fos protein in neurons associated with nociception, kinase c, dorsal horn, opioid receptor and spinal cord
2) Confidence 0.31 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15322678 Disease Relevance 0.09 Pain Relevance 0.88

General Comments

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