INT120931

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap2s1) vesicle-mediated transport (Ap2s1) Golgi apparatus (Ap2s1)
plasma membrane (Ap2s1)
Anatomy Link Frequency
SK-N-SH 1
Ap2s1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 99.96 Very High Very High Very High
fortral 6 99.36 Very High Very High Very High
antagonist 10 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 2 99.72 Very High Very High Very High
Neuroblastoma 2 99.28 Very High Very High Very High
Cancer 6 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To establish the activity of sigma ligands at sigma1 and sigma2 receptor, we chose two tumour cell lines, the human SK-N-SH neuroblastoma and the rat C6 glioma lines, which express sigma2 receptors at a high density and sigma1 receptors in their high-affinity or low-affinity state.
Gene_expression (express) of sigma2 in SK-N-SH associated with neuroblastoma, cancer and glioma
1) Confidence 0.02 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322732 Disease Relevance 0.37 Pain Relevance 0.33
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.
Gene_expression (effects) of sigma2 associated with fortral, cancer, antagonist and agonist
2) Confidence 0.02 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 15322732 Disease Relevance 0.43 Pain Relevance 0.57

General Comments

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