INT120967

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 23.67
Pain Relevance 8.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
myocardium 6
cardiomyocyte 4
nerve 2
HTC 2
soleus 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 395 100.00 Very High Very High Very High
antagonist 132 99.98 Very High Very High Very High
Morphine 17 99.98 Very High Very High Very High
qutenza 7 99.68 Very High Very High Very High
Paracetamol 240 99.52 Very High Very High Very High
Dopamine 71 99.46 Very High Very High Very High
Thalamus 2 98.30 Very High Very High Very High
analgesia 65 97.36 Very High Very High Very High
Nerve growth factor 35 97.08 Very High Very High Very High
cva 24 96.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 478 99.78 Very High Very High Very High
Hyperglycemia 72 99.76 Very High Very High Very High
Aging 152 99.66 Very High Very High Very High
Stress 167 99.52 Very High Very High Very High
Myocardial Infarction 722 99.44 Very High Very High Very High
Lactic Acidosis 1 98.40 Very High Very High Very High
Diabetes Mellitus 760 98.36 Very High Very High Very High
Hypertrophy 130 97.84 Very High Very High Very High
Death 80 97.36 Very High Very High Very High
Hypothermia 138 97.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by AMPH is followed by a delayed decrease in protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH-induced behavioral sensitization.
Negative_regulation (decrease) of Neg (not) Spec (whether) Phosphorylation (phosphorylation) of Akt
1) Confidence 0.57 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.28
This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.
Negative_regulation (reducing) of Phosphorylation (phosphorylation) of Akt associated with paracetamol and aging
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.50 Pain Relevance 0.40
Moreover, the effect of high glucose on ROS generation, Akt/tuberin phosphorylation, OGG1 downregulation, and 8-oxodG accumulation is markedly reduced by the antioxidant NAC.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.48 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.43 Pain Relevance 0
Key changes in the posttranslational modification and expression of stress response proteins were decreased Akt phosphorylation and a concomitant increase in FOXO3a activation.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt associated with stress
4) Confidence 0.47 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.94 Pain Relevance 0.09
Phosphorylation of Akt kinase was decreased in GK rat hearts 12 weeks post MI compared to post-MI Wistar rats (Figure 5B).
Negative_regulation (decreased) of Phosphorylation (Phosphorylation) of Akt kinase in hearts associated with myocardial infarction
5) Confidence 0.47 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.03 Pain Relevance 0.03
In the present study, we showed that decreased Akt phosphorylation in the post-infarct GK rat myocardium was associated with a decrease in the phosphorylation of FOXO3a at Akt-preferred Ser253 amino acid.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt in myocardium
6) Confidence 0.47 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.84 Pain Relevance 0
In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt in cardiomyocyte associated with apoptosis and myocardial infarction
7) Confidence 0.47 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.46 Pain Relevance 0.13
However, Akt is an important mediator of RISK signaling, and inhibition of the up-stream PI3-kinase with either Wortmannin or LY 294002 reduced Akt phosphorylation and abolished IPC-mediated protection [21, 32].
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt
8) Confidence 0.46 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.08 Pain Relevance 0.15
The down-regulation of nerve growth factor (NGF) mRNA and protein expression in the cortex and thalamus at defined time points between 1 and 24h after the propofol treatment, as well as a decrease of phosphorylated Akt were observed.
Negative_regulation (decrease) of Phosphorylation (phosphorylated) of Akt in nerve associated with nerve growth factor and thalamus
9) Confidence 0.46 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19150648 Disease Relevance 0.53 Pain Relevance 0.30
Moreover, an inhibitor of glycogen synthase kinase-3beta (GSK3beta), a kinase whose activity is blocked by Akt-mediated phosphorylation, promoted mitochondrial movement.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.43 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17904380 Disease Relevance 0 Pain Relevance 0.25
Furthermore, inhibition of Epac1 with siRNA had no effect on roflumilast-induced CREB phosphorylation, whereas inhibited Akt phosphorylation, implicating that Akt phosphorylation was regulated by Epac pathway.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Akt
11) Confidence 0.43 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18276108 Disease Relevance 0.39 Pain Relevance 0.03
Aging-associated hyper-phosphorylation of Akt can be attenuated by chronic acetaminophen treatment
Negative_regulation (attenuated) of Phosphorylation (-) of Akt associated with paracetamol and aging
12) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.74 Pain Relevance 0.56
Aging-associated hyper-phosphorylation of Akt can be attenuated by chronic acetaminophen treatment
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of Akt associated with paracetamol and aging
13) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.74 Pain Relevance 0.56
The phosphorylation of the GSK-3 fusion protein at Ser21/Ser9 by the immunoprecipitated Akt was detected by immunoblotting.
Negative_regulation (detected) of Phosphorylation (phosphorylation) of Akt
14) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.05 Pain Relevance 0
It is also possible that events typical of enhanced protein translation initiation occur in the myocardium during early endotoxaemia, but this remains speculative with the lack of a robust reduction of AKT phosphorylation in fast-twitch muscle.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of AKT in myocardium
15) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Moreover, Dex induced an association of GR with the regulatory subunit of PI3K, p85alpha, in a ligand-dependent manner and promoted serine/threonine kinase Akt phosphorylation that was blocked by coadministration of mifepristone or LY294002.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Akt
16) Confidence 0.38 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15523051 Disease Relevance 0.22 Pain Relevance 0.39
Moreover, a decrease in Akt phosphorylation in the presence of LY294002 (Fig. 4A) and Wortmannin (Fig. 4C) significantly attenuated the downregulation of OGG1 by high glucose (Fig. 4B and D).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Akt
17) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
PI 3-kinase/Akt pathways mediate high glucoseĀ–induced Akt phosphorylation and OGG1 protein downregulation in MCT cells.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of Akt
18) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
Figure 4A shows that glucose-induced Akt phosphorylation is prevented by both inhibitors.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of Akt
19) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
Moreover, pretreatment of the cells with NAC inhibited Akt and tuberin phosphorylation and upregulation of OGG1 protein expression in cells exposed to high glucose (Fig. 7D).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Akt
20) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0

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