INT12097

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.76
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
Anatomy Link Frequency
liver 1
common bile duct 1
platelets 1
urine 1
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 13 99.46 Very High Very High Very High
Pain 1 98.10 Very High Very High Very High
Bile 1 97.60 Very High Very High Very High
addiction 14 96.24 Very High Very High Very High
Glutamate 1 91.52 High High
depression 1 90.24 High High
Paracetamol 9 86.32 High High
headache 1 85.16 High High
lidocaine 2 83.32 Quite High
antagonist 2 70.28 Quite High
Disease Link Frequency Relevance Heat
Nephrotoxicity 4 98.88 Very High Very High Very High
Jaundice 1 98.42 Very High Very High Very High
Alcohol Addiction 10 98.32 Very High Very High Very High
Pain 1 98.10 Very High Very High Very High
Drug Dependence 5 96.64 Very High Very High Very High
Pancreatitis 5 94.76 High High
Injury 9 94.64 High High
Fever 13 92.40 High High
Sleep Disorders 1 90.64 High High
Depression 1 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tests for total protein, albumin, LDH, AST, ALT, GGT, amylase, lipase, and cholesterol were significantly affected to various extents at different HBOC concentrations on the Hitachi 747 and Vitros 750.
Regulation (affected) of GGT
1) Confidence 0.44 Published 1997 Journal Clin. Chem. Section Abstract Doc Link 9299968 Disease Relevance 0.07 Pain Relevance 0.08
The role of clinical (biliary pain and/or jaundice), laboratory (discriminant function (DF) calculated using AST, ALT, AlkPh and GGT serum values) and ultrasonographic (US)(dilation and/or stone of common bile duct (CBD)) findings in identification of the biliary etiology of acute pancreatitis (AP) was studied in 60 patients.
Regulation (values) of GGT in common bile duct associated with pain, bile, pancreatitis and jaundice
2) Confidence 0.26 Published 1992 Journal Recenti Prog Med Section Abstract Doc Link 1626115 Disease Relevance 0.85 Pain Relevance 0.15
Particularly useful laboratory indicators of alcoholism include elevated levels of GGT and MCV, both displaying high specificity, with the GGT level being the most sensitive.
Regulation (sensitive) of GGT associated with alcohol addiction
3) Confidence 0.26 Published 1993 Journal Prim. Care Section Abstract Doc Link 8464947 Disease Relevance 1.46 Pain Relevance 0.54
The primary efficacy variable was time to first episode of heavy drinking; secondary efficacy assessments included time to first drink, alcohol consumption, craving, and changes in the serum biological markers gamma-glutamyl transferase (GGT), and aspartate and alanine aminotransferases.
Regulation (changes) of GGT associated with alcohol
4) Confidence 0.26 Published 2000 Journal Alcohol Alcohol. Section Abstract Doc Link 11093966 Disease Relevance 0.41 Pain Relevance 0.55
The mean values of GGT, alanine aminotransferase (ALT), AST, and bilirubin showed a transient increase 24 hours after the first and second infusion.
Regulation (values) of GGT
5) Confidence 0.26 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 1.33 Pain Relevance 0.11
No significant changes in liver enzyme activities (ALT, AST, GGT, ALP) were evident.
Neg (No) Regulation (changes) of GGT in liver
6) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000109 Disease Relevance 0.36 Pain Relevance 0.03
The mean values for erythrocytes, haemoglobin, globular volume, platelets, ALT, AST, GGT, ALP, IB and calcium remained within the normal ranges for all dogs [19].
Regulation (values) of GGT in platelets
7) Confidence 0.26 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC3022551 Disease Relevance 0.83 Pain Relevance 0.06
Nephrotoxicity was also indicated at both timepoints by an increased creatinine concentration in plasma, while neither the urine volume nor its content in gamma-glutamyl transpeptitase over 20 h were affected.
Neg (neither) Regulation (affected) of gamma-glutamyl transpeptitase in urine associated with nephrotoxicity
8) Confidence 0.01 Published 1988 Journal J Appl Toxicol Section Abstract Doc Link 2846674 Disease Relevance 0.46 Pain Relevance 0.43

General Comments

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