INT120970

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.65
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) plasma membrane (Irs1) nucleus (Irs1)
cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
liver 1
muscle 1
chromaffin cells 1
adipose tissue 1
soleus 1
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 2 98.56 Very High Very High Very High
Calcium channel 1 98.06 Very High Very High Very High
tolerance 39 97.36 Very High Very High Very High
sodium channel 1 97.16 Very High Very High Very High
Nav1.7 1 96.86 Very High Very High Very High
cytokine 51 96.40 Very High Very High Very High
ischemia 2 92.44 High High
corticosteroid 96 86.44 High High
Inflammation 115 82.92 Quite High
vagus nerve 1 70.72 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 171 99.56 Very High Very High Very High
Diabetes Mellitus 262 99.20 Very High Very High Very High
Disease 34 98.28 Very High Very High Very High
Obesity 66 96.36 Very High Very High Very High
Stress 47 95.56 Very High Very High Very High
Cv Unclassified Under Development 2 92.44 High High
Sepsis 189 90.96 High High
Cognitive Disorder 4 90.08 High High
Apoptosis 64 89.32 High High
Hyperinsulinism 3 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with a previous report that reduction of IRS-1 mRNA is seen 24 h following IL-6 treatment in adipose cells (Rotter et al. 2003).
Negative_regulation (reduction) of IRS-1 mRNA
1) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
In contrast, the IRS-1 protein (Fig. 5A) was significantly decreased in insulin-treated diabetes compared with control (47% of control, P < 0.001).
Negative_regulation (decreased) of IRS-1 protein associated with diabetes mellitus
2) Confidence 0.33 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.60 Pain Relevance 0.10
The present data revealed that insulin + GJG treatment inhibits the increased IRS-1 tyrosine phosphorylation levels (Fig. 5B); therefore, these improvements are thought to improve the abnormal activation of PI 3-kinase (8,9) resulting in the correction of decreased efficiency of glucose metabolization.
Negative_regulation (inhibits) of IRS-1
3) Confidence 0.33 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.36 Pain Relevance 0
and IRS-1 were significantly inhibited in insulin combined with GJG treated diabetes.
Negative_regulation (inhibited) of IRS-1 associated with diabetes mellitus
4) Confidence 0.33 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC538504 Disease Relevance 0.69 Pain Relevance 0
A decline of IRS-1 amount or function has been linked to decreased glucose uptake in insulin resistant animal models and type II diabetic patients (Sesti et al. 2001; Smith, 2002).
Negative_regulation (decline) of IRS-1 associated with diabetes mellitus
5) Confidence 0.27 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.56 Pain Relevance 0.17
In the infusion study, IRS-1 mRNA declines following drug treatment and reaches a steady-state throughout the 7-day study.


Negative_regulation (declines) of IRS-1 mRNA
6) Confidence 0.27 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
The proposed PK/PD model reasonably captured the down-regulation of IRS-1 message by MPL administration (Fig. 8).
Negative_regulation (regulation) of IRS-1
7) Confidence 0.27 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Apart from IR protein levels, infusion of beta-endorphin reversed the decrease in protein expression for the IRS-1, p85 regulatory subunit of PI3-kinase, and Akt serine phosphorylation in soleus muscle in fructose-fed rats.
Negative_regulation (decrease) of IRS-1 in soleus
8) Confidence 0.25 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.38 Pain Relevance 0.15
, IRS-1 and GLUT4 protein, were impaired in the GK rat heart [39] which, at least in theory could affect the ability of the GK rat heart to respond to stress adequately.
Negative_regulation (impaired) of IRS-1 in heart associated with stress
9) Confidence 0.20 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.08 Pain Relevance 0.05
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Negative_regulation (reduction) of IRS-1 in adipose tissue associated with obesity and insulin resistance
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Negative_regulation (reduction) of IRS-1 in muscle associated with obesity and insulin resistance
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Negative_regulation (reduction) of IRS-1 in liver associated with obesity and insulin resistance
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15
In fact, defects in glucose utilization, a striking reduction in insulin receptor mRNA levels, and attenuated insulin signaling, as evidenced by decreased IRS-1, PI3K, and pAKT have been demonstrated in AD [33].
Negative_regulation (decreased) of IRS-1 associated with disease
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.93 Pain Relevance 0.04
In adrenal chromaffin cells, GSK-3 inhibition caused up-regulation of voltage-dependent Nav1.7 sodium channel, enhancing voltage-dependent calcium channel gating and catecholamine exocytosis; conversely, chronic treatment with GSK-3 inhibitors caused down-regulation of insulin receptor, IRS-1, IRS-2, and Akt1 levels.
Negative_regulation (down-regulation) of IRS-1 in chromaffin cells associated with catecholamine, calcium channel, sodium channel and nav1.7
14) Confidence 0.02 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273146 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox