INT121010

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 12
Disease Relevance 2.84
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Por) oxidoreductase activity (Por) endoplasmic reticulum (Por)
enzyme binding (Por)
Anatomy Link Frequency
testis 10
liver 4
kidney 4
brain 1
adrenal gland 1
Por (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Embryonic Lethality 12 95.76 Very High Very High Very High
Lipidosis 12 94.80 High High
Body Weight 12 82.32 Quite High
Targeted Disruption 24 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of Gene_expression (expression) of CPR in testis
1) Confidence 0.58 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
In addition, despite apparently compensatory increases in total microsomal cytochrome P450 content in the liver and kidney, the decreases in CPR expression were accompanied by reductions in systemic clearance of pentobarbital, as well as in hepatic microsomal metabolism of acetaminophen and testosterone.
Negative_regulation (decreases) of Gene_expression (expression) of CPR in kidney associated with paracetamol
2) Confidence 0.37 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.33 Pain Relevance 0.10
In the liver, a pattern of pericentral distribution of CPR protein was preserved in the Cpr(low/low) mice, despite an overall reduction in CPR expression.
Negative_regulation (reduction) of Gene_expression (expression) of CPR in liver
3) Confidence 0.37 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.31 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in brain Gene_expression (expression) of CPR in testis
4) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in ovary Gene_expression (expression) of CPR in testis
5) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in adrenal gland Gene_expression (expression) of CPR in testis
6) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in olfactory mucosa Gene_expression (expression) of CPR in testis
7) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in lung Gene_expression (expression) of CPR in testis
8) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in liver Gene_expression (expression) of CPR in testis
9) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in kidney Gene_expression (expression) of CPR in testis
10) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
The Cpr gene in these mice was disrupted by the insertion of a neo gene in intron 15, which led to 74 to 95% decreases in CPR expression in all tissues examined, including olfactory mucosa, adrenal gland, brain, testis, ovary, lung, kidney, liver, and heart.
Negative_regulation (decreases) of in heart Gene_expression (expression) of CPR in testis
11) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.21 Pain Relevance 0
In addition, despite apparently compensatory increases in total microsomal cytochrome P450 content in the liver and kidney, the decreases in CPR expression were accompanied by reductions in systemic clearance of pentobarbital, as well as in hepatic microsomal metabolism of acetaminophen and testosterone.
Negative_regulation (decreases) of in liver Gene_expression (expression) of CPR in kidney associated with paracetamol
12) Confidence 0.13 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15328377 Disease Relevance 0.33 Pain Relevance 0.10

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