INT121027

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 103 95.76 Very High Very High Very High
cytokine 9 10.00 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 100.00 Very High Very High Very High
Osteoarthritis 104 95.76 Very High Very High Very High
Stress 2 50.00 Quite Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we investigated the effect of MKK3 or MKK6 knock down on the phosphorylation of p38-MAPK in response to stimulation with IL-1?
Spec (investigated) Regulation (effect) of Phosphorylation (phosphorylation) of p38 associated with targeted disruption
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.10 Pain Relevance 0.46
Suppression of AP-1 was associated with altered phosphorylation of p38 mitogen-activated protein kinases.
Regulation (altered) of Phosphorylation (phosphorylation) of p38
2) Confidence 0.14 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0

General Comments

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