INT121036

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.34
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
liver 4
PGE2 4
neurons 2
A549 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 35 100.00 Very High Very High Very High
Inflammation 89 99.84 Very High Very High Very High
Arthritis 10 96.24 Very High Very High Very High
dexamethasone 7 93.36 High High
cINOD 49 89.84 High High
agonist 7 88.92 High High
aspirin 60 83.36 Quite High
cytokine 52 61.28 Quite High
Inflammatory response 21 55.64 Quite High
Inflammatory marker 1 27.52 Quite Low
Disease Link Frequency Relevance Heat
Hemophilus Infection 89 99.98 Very High Very High Very High
INFLAMMATION 129 99.84 Very High Very High Very High
Pancreatic Cancer 84 99.84 Very High Very High Very High
Cancer 90 98.12 Very High Very High Very High
Arthritis 9 96.24 Very High Very High Very High
Infection 12 95.52 Very High Very High Very High
Parkinson's Disease 108 93.84 High High
Apoptosis 41 93.24 High High
Adenocarcinoma 8 93.12 High High
Targeted Disruption 41 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased PGE2 production has been shown to be mainly due to an increase in COX activity, which is, in turn, due to an increase in COX-2 protein and mRNA expression.
Positive_regulation (increase) of Transcription (expression) of COX
1) Confidence 0.21 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.42 Pain Relevance 0.10
From the COX-2 inhibitor study (Fig. 5C &5D), the number of TH-positive neurons was strongly positively correlated with the number of Nissl-stained neurons and the amount of the COX-2 inhibitor administered per day (rs ?
Positive_regulation (neurons) of Transcription (amount) of COX in neurons associated with cox-2 inhibitor
2) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.27 Pain Relevance 0.13
Elevated COX-2 mRNA represents a higher transcription rate rather than an altered stability of COX-2 mRNA.
Positive_regulation (stability) of Transcription (transcription) of COX
3) Confidence 0.15 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.40 Pain Relevance 0.10
Ceramide up-regulates COX-2 transcription by increasing activation of transcription factor NF-kappaB.
Positive_regulation (up-regulates) of Transcription (transcription) of COX
4) Confidence 0.13 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.16 Pain Relevance 0.05
COX-2 mRNA expression was markedly induced in the spleen of LPS treated animals (44.8 ± 5.0-fold over control) and increased to a lesser extent in liver (4.6 ± 0.9) (Fig. 6).
Positive_regulation (induced) of Transcription (expression) of COX in liver
5) Confidence 0.11 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.05 Pain Relevance 0.03
COX-2 mRNA expression was markedly induced in the spleen of LPS treated animals (44.8 ± 5.0-fold over control) and increased to a lesser extent in liver (4.6 ± 0.9) (Fig. 6).
Positive_regulation (increased) of Transcription (expression) of COX in liver
6) Confidence 0.11 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.06 Pain Relevance 0.03
mice used in this study had an insertion into intron 11, resulting in transcription of an inactive “COX-1” protein (7).
Positive_regulation (resulting) of Transcription (transcription) of COX
7) Confidence 0.09 Published 2008 Journal FASEB J Section Body Doc Link PMC2691413 Disease Relevance 0.57 Pain Relevance 0.20
One report showed that levels of COX-2 mRNA were more than 60-fold increased in pancreatic cancer compared to adjacent non-tumor tissue [36].
Positive_regulation (increased) of Transcription (levels) of COX associated with cancer and pancreatic cancer
8) Confidence 0.06 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.93 Pain Relevance 0.30
induces COX-2 transcription in inflammatory cells (19).
Positive_regulation (induces) of Transcription (transcription) of COX associated with inflammation
9) Confidence 0.06 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.99 Pain Relevance 0.59
NTHi induced COX-2 mRNA expression in a dose-dependent manner, but not COX-1 mRNA expression in A549 cells.
Positive_regulation (induced) of Transcription (expression) of COX in A549 associated with hemophilus infection
10) Confidence 0.03 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.29 Pain Relevance 0
Increased transcription of COX-2 also leads to excessive production of PGE2 that in turn forms a stimulatory loop with many biologic functions (proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis), which may result in the development of CRC.
Positive_regulation (Increased) of Transcription (transcription) of COX in PGE2 associated with colon cancer and apoptosis
11) Confidence 0.03 Published 2006 Journal Adv Anat Pathol Section Abstract Doc Link 16998321 Disease Relevance 0.59 Pain Relevance 0.25
Increased transcription of COX-2 also leads to excessive production of PGE2 that in turn forms a stimulatory loop with many biologic functions (proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis), which may result in the development of CRC.
Positive_regulation (leads) of Transcription (transcription) of COX in PGE2 associated with colon cancer and apoptosis
12) Confidence 0.02 Published 2006 Journal Adv Anat Pathol Section Abstract Doc Link 16998321 Disease Relevance 0.59 Pain Relevance 0.25

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