INT121037

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.56
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
chondrocytes 4
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 206 99.36 Very High Very High Very High
Inflammation 192 81.52 Quite High
Inflammatory stimuli 2 79.24 Quite High
cytokine 22 70.68 Quite High
cINOD 10 51.56 Quite High
Inflammatory response 14 32.32 Quite Low
COX2 1 25.00 Low Low
Arthritis 16 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 208 99.36 Very High Very High Very High
Stress 22 98.40 Very High Very High Very High
Aging 18 97.04 Very High Very High Very High
Burns 2 85.04 High High
INFLAMMATION 211 81.52 Quite High
Obesity 131 72.72 Quite High
Disease 15 56.56 Quite High
Neurodegenerative Disease 1 48.08 Quite Low
Arthritis 18 45.16 Quite Low
Weight Loss 4 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.
Positive_regulation (caused) of Positive_regulation (increase) of TFAM
1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (caused) of Positive_regulation (increase) of transcription factor
2) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
-induced activation of transcription factor RUNX-2 in human OA chondrocytes
Positive_regulation (induced) of Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis
3) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.37
induced activation and DNA binding activity of the transcription factor RUNX2 in human OA chondrocytes.
Positive_regulation (induced) of Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis
4) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.89 Pain Relevance 0.42
Ceramide up-regulates COX-2 transcription by increasing activation of transcription factor NF-kappaB.
Positive_regulation (increasing) of Positive_regulation (activation) of transcription factor
5) Confidence 0.01 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.11 Pain Relevance 0.05
Both omega-3 fatty acids appear to provide a similar activation of this gene transcription factor [107].
Positive_regulation (provide) of Positive_regulation (activation) of transcription factor
6) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.50 Pain Relevance 0.17

General Comments

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