INT121037

Context Info Confidence 0.42 First Reported 2004 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.56 Pain Relevance 1.02

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency chondrocytes 4 TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 206 99.36 Inflammation 192 81.52 Inflammatory stimuli 2 79.24 cytokine 22 70.68 cINOD 10 51.56 Inflammatory response 14 32.32 COX2 1 25.00 Arthritis 16 5.00 Pain 13 5.00 metalloproteinase 12 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 208 99.36 Stress 22 98.40 Aging 18 97.04 Burns 2 85.04 INFLAMMATION 211 81.52 Obesity 131 72.72 Disease 15 56.56 Neurodegenerative Disease 1 48.08 Arthritis 18 45.16 Weight Loss 4 39.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.

Positive_regulation (caused) of Positive_regulation (increase) of TFAM

1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Positive_regulation (caused) of Positive_regulation (increase) of transcription factor

2) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

-induced activation of transcription factor RUNX-2 in human OA chondrocytes

Positive_regulation (induced) of Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis

3) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.37

induced activation and DNA binding activity of the transcription factor RUNX2 in human OA chondrocytes.

Positive_regulation (induced) of Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis

4) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.89 Pain Relevance 0.42

Ceramide up-regulates COX-2 transcription by increasing activation of transcription factor NF-kappaB.

Positive_regulation (increasing) of Positive_regulation (activation) of transcription factor

5) Confidence 0.01 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.11 Pain Relevance 0.05

Both omega-3 fatty acids appear to provide a similar activation of this gene transcription factor [107].

Positive_regulation (provide) of Positive_regulation (activation) of transcription factor

6) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.50 Pain Relevance 0.17

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