INT12104

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 28.94
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
plasma 2
TMJ 1
platelet 1
fibroblast 1
blood 1
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 240 100.00 Very High Very High Very High
Inflammation 246 99.60 Very High Very High Very High
Osteoarthritis 70 97.52 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 3 97.24 Very High Very High Very High
cINOD 32 97.20 Very High Very High Very High
bradykinin 21 93.92 High High
Snapping jaw 4 91.64 High High
Pain 27 90.96 High High
Angina 4 88.84 High High
fibrosis 85 84.80 Quite High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 50 99.96 Very High Very High Very High
Breast Cancer 327 99.88 Very High Very High Very High
Metastasis 180 99.82 Very High Very High Very High
INFLAMMATION 270 99.60 Very High Very High Very High
Coronary Artery Disease 10 99.52 Very High Very High Very High
Necrosis 17 99.32 Very High Very High Very High
Cancer 657 99.24 Very High Very High Very High
Thrombosis 79 98.92 Very High Very High Very High
Obesity 97 97.94 Very High Very High Very High
Osteoarthritis 74 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasminogen activation controls the formation of complement anaphylotoxins (responsible for vasodilatation, increase of venular permeability and leukocyte chemotaxis) and of bradykinin (which accounts for vasodilatation, increase of venular permeability and pain) by regulating the plasma contact system.
Positive_regulation (activation) of Plasminogen in plasma associated with pain, increased venous pressure under development and bradykinin
1) Confidence 0.68 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.64 Pain Relevance 0.31
The activation of plasminogen into plasmin is mediated by two types of activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA).
Positive_regulation (activation) of plasmin
2) Confidence 0.67 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18473800 Disease Relevance 0.22 Pain Relevance 0
By binding to plasminogen, tetranectin may enhance activation of plasminogen to plasmin, which plays a role in the degradation of extracellular proteins and cancer progression.
Positive_regulation (activation) of plasmin associated with cancer
3) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.20 Pain Relevance 0
These results clearly demonstrated increased levels of PA, plasmin and kallikrein activities in the synovial fluid of patients with ID and OA, and suggest that these enzymes may be involved in the pathogenesis of synovitis, as well as the resorption of cartilage and bone in TMJ.
Positive_regulation (increased) of plasmin in TMJ associated with snapping jaw, synovitis and osteoarthritis
4) Confidence 0.67 Published 2001 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11518356 Disease Relevance 0.68 Pain Relevance 0.33
From its discovery in 1986 tetranectin (TN) has been suggested to participate in proteolytic processes through its binding to plasminogen, which enhances the activation of plasminogen to plasmin.
Positive_regulation (activation) of plasmin
5) Confidence 0.67 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.25 Pain Relevance 0
The findings are helpful for the discovery of patients with enhanced plasminogen activator levels in synovia which should be treated therapeutically.
Positive_regulation (enhanced) of plasminogen
6) Confidence 0.66 Published 1989 Journal Z Rheumatol Section Abstract Doc Link 2609796 Disease Relevance 0.44 Pain Relevance 0.27
From its discovery in 1986 tetranectin (TN) has been suggested to participate in proteolytic processes through its binding to plasminogen, which enhances the activation of plasminogen to plasmin.
Positive_regulation (activation) of plasminogen
7) Confidence 0.57 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.24 Pain Relevance 0
Anistreplase, a new thrombolytic drug, is a complex of streptokinase and acylated human plasminogen that can be administered by intravenous bolus and activates plasminogen at the clot site.
Positive_regulation (activates) of plasminogen
8) Confidence 0.50 Published 1992 Journal Angiology Section Abstract Doc Link 1626735 Disease Relevance 0.46 Pain Relevance 0.06
In patients with restenosis, plasminogen activator inhibitor type-1 (PAI-1) levels were significantly higher (88.2 +/- 36.1 vs 118.5 +/- 50.0 ng/dl; p< 0.05) and plasmin-plasmin inhibitor complex (PIC) levels were significantly lower (0.76 +/- 0.26 vs 0.61 +/- 0.26 microg/ml; p < 0.02) than at baseline.
Positive_regulation (higher) of plasmin associated with cardiovascular disease
9) Confidence 0.49 Published 1997 Journal Am. Heart J. Section Abstract Doc Link 9124158 Disease Relevance 0.65 Pain Relevance 0.31
The generation of plasmin is important for the degradation of components of the extra cellular matrix (ECM) by activating matrix metalloproteases (MMPs) that breaks down interstitial collagens.
Positive_regulation (generation) of plasmin
10) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.30 Pain Relevance 0.08
However, our demonstration of a direct requirement of plasmin in the activation of proMMP-13 suggests that this fibrillar collagenase may play a prominent role in the degradative activity of breast cancer cells.
Positive_regulation (requirement) of plasmin associated with breast cancer
11) Confidence 0.49 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.54 Pain Relevance 0.26
However, extensive plasmin activity also induces proteolysis of fibrinogen and coagulation factors which inhibit thrombosis by interfering with fibrin polymerization and platelet aggregation thus exerting an anticoagulant effect.
Positive_regulation (induces) of plasmin in platelet associated with thrombosis
12) Confidence 0.49 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.34 Pain Relevance 0
We have developed a dog model for ex vivo measurement of the fibrinolytic activity using a spectrophotometric assay employing human plasminogen, chromogenic plasmin substrate and human fibrinogen-BrCN digests for the stimulation of t-PA.
Positive_regulation (stimulation) of plasmin
13) Confidence 0.49 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 2840752 Disease Relevance 0 Pain Relevance 0.04
= tumor necrosis factor-alpha; TTBS 1× = Tris 20 mM, NaCl 150 mM (pH 7.5), and 0.1% Tween 20; uPA = urokinase plasminogen activator.


Positive_regulation (activator) of plasmin associated with necrosis and cancer
14) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.46 Pain Relevance 0.21
There are two types of plasminogen activators (PA), the urokinase-type (uPA) and the tissue-type (tPA). uPA is generally agreed to be the enzyme of most relevance to tumor biology, while the primary role of tPA is generation of plasmin for fibrinolysis in blood vessels.
Positive_regulation (generation) of plasmin in blood vessels associated with cancer
15) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.59 Pain Relevance 0
In addition, factor XIIa and plasmin may serve to activate C1 in the complement pathway, while factor XIIa or kallikrein in the contact pathway may generate plasmin from plasminogen in the fibrinolytic pathway [20].
Spec (may) Positive_regulation (generate) of plasmin
16) Confidence 0.45 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.46 Pain Relevance 0.11
E-aminocaproic acid inhibits fibrinolysis by preventing the activation of plasminogen to plasmin.
Positive_regulation (activation) of plasmin
17) Confidence 0.45 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2938536 Disease Relevance 0.70 Pain Relevance 0.06
Myocardial ischaemia is associated with the activation of MMPs and the serine proteinase plasmin.
Positive_regulation (activation) of plasmin associated with coronary artery disease and metalloproteinase
18) Confidence 0.45 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.40 Pain Relevance 0.11
Staphylokinase (SAK) is a secreted protein that binds and activates surface-bound plasminogen into plasmin, which may enhance bacterial invasion through host tissues.
Positive_regulation (activates) of plasmin
19) Confidence 0.45 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.07 Pain Relevance 0
If this finding can be extrapolated to lungs, it may suggest that lung fibroblasts could also participate in the synthesis of the major negative physiologic regulator of plasmin activation and, consequently, in the excessive alveolar fibrin accumulation [43].


Positive_regulation (activation) of plasmin in lungs
20) Confidence 0.45 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.72 Pain Relevance 0.23

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