INT121050

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.60
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Pomc) extracellular region (Crh, Pomc) cytoplasm (Crh, Pomc)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
anterior pituitary 4
Crh (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 76.72 Quite High
cytokine 13 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 34 94.76 High High
Pain 4 76.72 Quite High
Aggression 1 41.00 Quite Low
Emergencies 1 30.88 Quite Low
Shock 1 30.20 Quite Low
Hypertension 1 27.56 Quite Low
Pressure Volume 2 Under Development 2 9.60 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that CRH has little influence on the basal release of ACTH and prohormone convertase-2 processing enzyme.
CRH Neg (little) Regulation (influence) of Localization (release) of ACTH
1) Confidence 0.43 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.15 Pain Relevance 0.08
Corticotropin-releasing hormone (CRH) mainly regulates the synthesis and secretion of adrenocorticotropin (ACTH) in the anterior pituitary (AP).
Corticotropin-releasing hormone Regulation (regulates) of Localization (secretion) of ACTH in anterior pituitary
2) Confidence 0.26 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.15 Pain Relevance 0.07
Corticotropin-releasing hormone (CRH) mainly regulates the synthesis and secretion of adrenocorticotropin (ACTH) in the anterior pituitary (AP).
CRH Regulation (regulates) of Localization (secretion) of ACTH in anterior pituitary
3) Confidence 0.26 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.15 Pain Relevance 0.07
Compared with CRH, vasopressin itself has a weak ability of up-regulating the ACTH secretion; however, it markedly potentiates the effect of CRH (Gilles et al. 1982; DeBold et al. 1984; Volpi et al. 2004).
CRH Regulation (regulating) of Localization (secretion) of ACTH
4) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.16 Pain Relevance 0

General Comments

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