INT121089

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) intracellular (Adarb1) cytoplasm (Oprd1)
signal transducer activity (Oprd1) mRNA processing (Adarb1) RNA binding (Adarb1)
Oprd1 (Rattus norvegicus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 14 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
Kappa opioid receptor 4 92.96 High High
orphanin 1 90.64 High High
mu opioid receptor 5 75.68 Quite High
Potency 1 31.60 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LY255582 is a pan opioid selective receptor antagonist that has been shown to have high affinity for mu, delta, and kappa receptors in vitro.
opioid selective receptor Binding (affinity) of receptors associated with antagonist and opioid
1) Confidence 0.06 Published 2007 Journal Life Sci. Section Abstract Doc Link 17935738 Disease Relevance 0 Pain Relevance 0.35
Central administration of general and selective opioid receptor subtype antagonists in the rat has revealed a substantial role for mu, a moderate role for kappa, and a minimal role for delta receptors in the mediation of deprivation-induced feeding.
opioid receptor Binding (role) of receptors associated with antagonist and opioid receptor
2) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15333676 Disease Relevance 0 Pain Relevance 0.72

General Comments

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