INT121089

Context Info Confidence 0.06 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 1.07

nucleoplasm (Adarb1) intracellular (Adarb1) cytoplasm (Oprd1) signal transducer activity (Oprd1) mRNA processing (Adarb1) RNA binding (Adarb1)

Oprd1 (Rattus norvegicus) Adarb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 14 100.00 antagonist 8 100.00 Opioid 4 100.00 Kappa opioid receptor 4 92.96 orphanin 1 90.64 mu opioid receptor 5 75.68 Potency 1 31.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LY255582 is a pan opioid selective receptor antagonist that has been shown to have high affinity for mu, delta, and kappa receptors in vitro.

opioid selective receptor Binding (affinity) of receptors associated with antagonist and opioid

1) Confidence 0.06 Published 2007 Journal Life Sci. Section Abstract Doc Link 17935738 Disease Relevance 0 Pain Relevance 0.35

Central administration of general and selective opioid receptor subtype antagonists in the rat has revealed a substantial role for mu, a moderate role for kappa, and a minimal role for delta receptors in the mediation of deprivation-induced feeding.

opioid receptor Binding (role) of receptors associated with antagonist and opioid receptor

2) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15333676 Disease Relevance 0 Pain Relevance 0.72

General Comments

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