INT121100

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
Anatomy Link Frequency
plasma 2
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 4 97.92 Very High Very High Very High
fluoxetine 27 95.52 Very High Very High Very High
depression 42 75.16 Quite High
Serotonin 37 72.32 Quite High
noradrenaline 25 55.88 Quite High
Potency 3 53.88 Quite High
sSRI 41 5.00 Very Low Very Low Very Low
antidepressant 35 5.00 Very Low Very Low Very Low
Duloxetine 33 5.00 Very Low Very Low Very Low
tricyclic antidepressant 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 49 75.16 Quite High
Disorders Of Creatine Metabolism 1 25.36 Quite Low
Diarrhoea 2 8.08 Low Low
Major Depressive Disorder 27 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Xerostomia 7 5.00 Very Low Very Low Very Low
Reprotox - General 2 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Constipation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is an inhibitor of cytochrome P450 (CYP) 2D6 and other CYP enzymes, which increases the potential for drug interactions.
Positive_regulation (increases) of CYP Binding (interactions) of
1) Confidence 0.49 Published 2004 Journal Expert Opin Drug Saf Section Abstract Doc Link 15335304 Disease Relevance 0.08 Pain Relevance 0.45
In contrast with desvenlafaxine, the CYP2D6 genetic polymorphism has a significant influence on venlafaxine pharmacokinetics.122 Both drugs may have low potential for drug interactions, because of low protein binding and a relatively weak inhibitory effect on CYP isoenzymes.90,123 Nevertheless, increased plasma levels of imipramine, its metabolite desimipramine,124 and risperidone were associated with concomitant administration of venlafaxine.125 Furthermore, diphenhydramine may alter the disposition of venlafaxine via inhibition of CYP2D6.126 CYP3A4 inducers may enhance the clearance rate of desvenlafaxine.122
Positive_regulation (increased) of CYP Binding (binding) of in plasma
2) Confidence 0.08 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.08

General Comments

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