INT12111

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.63
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brainstem 2
blood 1
lateral 1
respiratory 1
Hbb-ar (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 1 99.84 Very High Very High Very High
Serotonin 9 99.66 Very High Very High Very High
imagery 61 99.60 Very High Very High Very High
Morphine 9 99.32 Very High Very High Very High
lidocaine 14 99.24 Very High Very High Very High
nalbuphine 1 98.52 Very High Very High Very High
medulla 90 98.48 Very High Very High Very High
anesthesia 22 97.72 Very High Very High Very High
Buprenorphine 1 96.84 Very High Very High Very High
Neurotransmitter 6 93.44 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 13 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 4 100.00 Very High Very High Very High
Cough 120 99.48 Very High Very High Very High
Syndrome 5 98.96 Very High Very High Very High
Pneumonia 250 98.84 Very High Very High Very High
Shock 35 98.28 Very High Very High Very High
Lateral Medullary Syndrome 5 97.68 Very High Very High Very High
Emergencies 30 97.26 Very High Very High Very High
Stroke 232 97.00 Very High Very High Very High
Hemiplegia 5 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buprenorphine substituted for morphine and significantly increased LCR values, whereas nalbuphine produced only partial (20-80%) morphine-key responding and significantly decreased LCR.
Negative_regulation (decreased) of LCR associated with nalbuphine, morphine and buprenorphine
1) Confidence 0.37 Published 2000 Journal Behav Pharmacol Section Abstract Doc Link 10821205 Disease Relevance 0 Pain Relevance 1.10
Cerebral hemispheric infarcts may, through mechanisms that are unclear at this time, suppress the LCR circuitry.
Negative_regulation (suppress) of LCR
2) Confidence 0.28 Published 2005 Journal Cough Section Body Doc Link PMC1277006 Disease Relevance 0.79 Pain Relevance 0.23
Suppression of the LCR tends to support our clinical observations that many cerebral hemispheric stroke patients, who show a transient or permanent impairment of the LCR, may have a condition we refer to as "brainstem shock."
Negative_regulation (Suppression) of LCR in brainstem associated with medulla, stroke and shock
3) Confidence 0.28 Published 2005 Journal Cough Section Body Doc Link PMC1277006 Disease Relevance 0.92 Pain Relevance 0.35
The LCR may be impaired in individuals who have a transient (e.g., post-general anesthesia) or permanent (e.g., post-stroke, cervical cord trauma, Parkinson's disease, amyotrophic lateral sclerosis) neurological event, which may affect the afferent, central or efferent components of the LCR [10-18].
Negative_regulation (impaired) of LCR in lateral associated with anesthesia, stroke, injury, disease and motor neuron diseases
4) Confidence 0.28 Published 2005 Journal Cough Section Body Doc Link PMC1277006 Disease Relevance 0.98 Pain Relevance 0.26
This study, using the present examination techniques for identifying neurological deficits in the emergency setting showed that subjects, who had a subsequent brainstem or cerebral hemispheric infarct identified by CT or MRI and a subsequently impaired LCR, were at risk of developing pneumonia.
Negative_regulation (impaired) of LCR in brainstem associated with medulla, emergencies, pneumonia and imagery
5) Confidence 0.28 Published 2005 Journal Cough Section Body Doc Link PMC1277006 Disease Relevance 0.99 Pain Relevance 0.21
Brainstem shock may be defined as a global neurological condition involving a transient or permanent impairment of one or more of the following vital functions: the reticular activating system, respiratory drive, or the LCR.
Negative_regulation (impairment) of LCR in respiratory associated with medulla and shock
6) Confidence 0.28 Published 2005 Journal Cough Section Body Doc Link PMC1277006 Disease Relevance 1.09 Pain Relevance 0.35
Acute cardiac decompensation in LCR rats was exclusively due to the development of intractable irregular ventricular contractions.
Negative_regulation (decompensation) of LCR associated with heart rate under development
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2699480 Disease Relevance 0.34 Pain Relevance 0
Left ventricular geometrical measures, however, showed a significantly larger ventricular diastolic dimension in LCR rats compared to HCR rats (LVDd [LCR] 9.1±0.2 vs.
Negative_regulation (dimension) of LCR
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.25 Pain Relevance 0
Intravenous lidocaine hydrochloride at 3 mg/kg produced no suppression of the LCR, LMR, or latency (SLN-ESAR onset latency before lidocaine 11.7 +/- 0.7 milliseconds, after lidocaine 12.2 +/- 0.5 milliseconds; peak latency before lidocaine 13.2 +/- 0.2 milliseconds, after lidocaine 13.4 +/- 0.4 milliseconds).
Neg (no) Negative_regulation (suppression) of LCR associated with lidocaine
9) Confidence 0.08 Published 1992 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 1626904 Disease Relevance 0.08 Pain Relevance 1.06
IFNalpha treatment is reported to produce: 1) a decrease in tryptophan availability for serotonin synthesis, 2) a decrease in the 5-HIAA level in the LCR, and 3) a modification of the central serotoninergic receptors.
Negative_regulation (decrease) of LCR associated with serotonin
10) Confidence 0.01 Published 2005 Journal Encephale Section Abstract Doc Link 16142050 Disease Relevance 0.40 Pain Relevance 0.66
Our findings shew that the intraoperative blood loss in LCR group and OCR group were 117.27 ± 65.21 ml and 159.39 ± 83.40 ml, prospectively.
Negative_regulation (loss) of LCR in blood associated with pressure volume 2 under development
11) Confidence 0.00 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 0.79 Pain Relevance 0

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