INT121117

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.41
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 12
Notch 4
neurons 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 64 99.72 Very High Very High Very High
Bioavailability 6 88.36 High High
metalloproteinase 43 86.60 High High
Inflammation 66 84.56 Quite High
cytokine 22 76.80 Quite High
headache 2 69.68 Quite High
Pain 1 67.76 Quite High
Kinase C 15 59.08 Quite High
Hippocampus 20 58.68 Quite High
antagonist 6 53.96 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 84 100.00 Very High Very High Very High
INFLAMMATION 97 99.44 Very High Very High Very High
Disease 584 97.92 Very High Very High Very High
Targeted Disruption 82 97.84 Very High Very High Very High
Apoptosis 147 83.96 Quite High
Necrosis 8 82.80 Quite High
Cancer 10 82.44 Quite High
Coma 2 78.44 Quite High
Frontotemporal Dementia 9 77.20 Quite High
Stress 62 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile.
Regulation (modulate) of Protein_catabolism (cleavage) of APP in Notch associated with inflammation, alzheimer's dementia and cinod
1) Confidence 0.62 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.35 Pain Relevance 0.45
In cultured cells, statins affect cleavage of the amyloid precursor protein via the ROCK kinase.
Regulation (affect) of Protein_catabolism (cleavage) of amyloid precursor protein in cleavage associated with alzheimer's dementia
2) Confidence 0.54 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC543463 Disease Relevance 0.27 Pain Relevance 0.03
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile.
Regulation (modulate) of Protein_catabolism (cleavage) of amyloid precursor protein in Notch associated with inflammation, alzheimer's dementia and cinod
3) Confidence 0.45 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.35 Pain Relevance 0.45
-secretase, the enzyme responsible for the second cleavage of APP, is another method to reduce the production of A?.
Regulation (responsible) of Protein_catabolism (cleavage) of APP in cleavage
4) Confidence 0.44 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.38 Pain Relevance 0.18
-secretase-dependent cleavage of APP generates the A?
Regulation (dependent) of Protein_catabolism (cleavage) of APP in cleavage
5) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.39 Pain Relevance 0.37
In relation to the cleavage of APP though, the basal shedding of the protein was unaffected in primary embryonic fibroblasts derived from ADAM17 knockout mice whereas the phorbol ester regulated cleavage was found to be deficient [69, 70].
Neg (unaffected) Regulation (unaffected) of Protein_catabolism (cleavage) of APP in cleavage associated with targeted disruption
6) Confidence 0.38 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.49 Pain Relevance 0.12
The authors propose that these data indicate that normal brain functions are facilitated by the regulated, activity-dependent cleavage of APP by BACE1 in neurons.
Regulation (regulated) of Protein_catabolism (cleavage) of APP in neurons
7) Confidence 0.24 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.30 Pain Relevance 0
A non-amyloidogenic pathway involves cleavage of APP by ?
Regulation (involves) of Protein_catabolism (cleavage) of APP in cleavage
8) Confidence 0.21 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.89 Pain Relevance 0.08
generated from deregulated proteolysis of the amyloid precursor protein (APP) undergoes accelerated A?
Regulation (deregulated) of Protein_catabolism (proteolysis) of APP associated with alzheimer's dementia
9) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 1.65 Pain Relevance 0
-secretase, and/or stabilize PS1 in a certain conformation, and thus affect the site of APP cleavage by ?
Regulation (affect) of Protein_catabolism (cleavage) of APP in cleavage
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.34 Pain Relevance 0.09

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