INT121119

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Aph1a) Golgi apparatus (Aph1a) endoplasmic reticulum (Aph1a)
Anatomy Link Frequency
Notch 1
Aph1a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 7 99.54 Very High Very High Very High
Abeta 12 45.04 Quite Low
Hippocampus 1 29.84 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2 99.84 Very High Very High Very High
INFLAMMATION 2 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile.
Protein_catabolism (cleavage) of gamma-secretase in Notch associated with inflammation, alzheimer's dementia and cinod
1) Confidence 0.13 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.35 Pain Relevance 0.45

General Comments

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