INT121126

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.83
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RNF34) ligase activity (RNF34)
Anatomy Link Frequency
plasma 1
MDA-MB-231 1
RNF34 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 97.64 Very High Very High Very High
antagonist 1 95.12 Very High Very High Very High
opioid receptor 1 94.68 High High
narcan 1 93.84 High High
COX-2 inhibitor 41 93.76 High High
addiction 8 89.72 High High
Buprenorphine 2 87.56 High High
aspirin 4 83.16 Quite High
cytokine 6 75.44 Quite High
cINOD 57 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 330 98.46 Very High Very High Very High
Burns 74 98.40 Very High Very High Very High
Acute Renal Failure 83 97.88 Very High Very High Very High
Benign Prostatic Hypertrophy 3 95.52 Very High Very High Very High
Death 32 95.20 Very High Very High Very High
Breast Cancer 168 91.64 High High
Starvation 2 87.28 High High
Cancer 247 79.52 Quite High
Pancreatic Cancer 5 75.00 Quite High
Adenocarcinoma 1 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study focused on the biological mechanisms of sensitivity and resistance to NCX 4040, highlighting that the cytotoxic action of this drug may be due to the hyperexpression of Bax, its translocation to the mitochondria, the release of Cytochrome C, and the activation of caspases-9 and -3, overall in a p53-independent manner.
Positive_regulation (activation) of caspases-9
1) Confidence 0.04 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699954 Disease Relevance 0.30 Pain Relevance 0.46
Expression levels of Bak and Bax, and the activation of caspases 3 and 7 in HUVECs significantly increased when treated with morphine.
Positive_regulation (activation) of caspases 3 associated with morphine
2) Confidence 0.03 Published 2009 Journal Toxicology Section Abstract Doc Link 19070643 Disease Relevance 0.58 Pain Relevance 0.96
Here, we found this kind of apoptosis was also accompanied by rapid loss of the mitochondrial membrane potential, followed by the efflux of cytochrome c from the mitochondria to the cytosol and the activation of caspases-9 and -3.
Positive_regulation (activation) of caspases-9 associated with apoptosis
3) Confidence 0.03 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15340216 Disease Relevance 0.93 Pain Relevance 0.25
Activation of caspases-3 and -7 and an elevated release of soluble Fas and Fas ligand have also been detected at the end of extracorporeal circulation [6,8,10].
Positive_regulation (Activation) of caspases-3 and -7
4) Confidence 0.02 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.82 Pain Relevance 0.10
mol/l) for 48 hours caused significant increases in activation of caspases 3 and 7 (fivefold increase at the 40 ?
Positive_regulation (activation) of caspases 3 and 7
5) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.65 Pain Relevance 0
In the highly invasive MDA-MB-231 cells, the mechanism of celecoxib-induced growth arrest was by induction of apoptosis, associated with reduced activation of protein kinase B/Akt, and subsequent activation of caspases 3 and 7.
Positive_regulation (activation) of caspases 3 and 7 in MDA-MB-231 associated with apoptosis
6) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1175053 Disease Relevance 0.47 Pain Relevance 0.03
At the molecular level, pAkt was inactivated with increased activation of proapoptotic protein Bax and caspases 3 and 7.
Positive_regulation (activation) of caspases 3 and 7
7) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.95 Pain Relevance 0.15
The activity of caspases 3, 8 and 9 significantly increased in tubular cells after incubation with burns septic ARF group plasma (Figure 4A).
Positive_regulation (increased) of caspases 3 in plasma associated with acute renal failure and burns
8) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.37 Pain Relevance 0
mol/l concentration of celecoxib, with increased activation of proapoptotic protein Bax and caspases 3 and 7 (Fig. 3).
Positive_regulation (increased) of caspases 3 and 7
9) Confidence 0.00 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.77 Pain Relevance 0.11

General Comments

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