INT121138

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.06
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
osteoblasts 3
chondrocytes 1
osteocytes 1
vertebral body 1
Ceacam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 97.16 Very High Very High Very High
anesthesia 4 83.92 Quite High
Pain 5 50.04 Quite High
substance P 7 50.00 Quite Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 1 97.00 Very High Very High Very High
Osteoporosis 46 96.28 Very High Very High Very High
Scoliosis 1 94.80 High High
Apoptosis 21 62.96 Quite High
Obesity 3 56.16 Quite High
Death 7 49.76 Quite Low
Hypertrophy 12 48.88 Quite Low
Peripheral Arterial Disease 1 28.32 Quite Low
Cancer 2 15.88 Low Low
Osteomyelitis 1 14.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Transcription (transcripts) of osteocalcin in osteocytes associated with metalloproteinase
1) Confidence 0.52 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.
Transcription (transcripts) of osteocalcin
2) Confidence 0.52 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31
During the fusion process a metaplastic shift appeared in the arch centra where cells in the intermediate zone between osteoblasts and chondrocytes co-transcribed col1a, col2a, runx2, osteocalcin and osteonectin, as visualized by ISH.
Transcription (transcribed) of osteocalcin in chondrocytes
3) Confidence 0.22 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.22 Pain Relevance 0
Osteocalcin was transcribed in osteogenic cells lining surfaces of trabeculae of fused vertebrae (Figure 6M) and in cells located abaxial in-between two opposing vertebral body endplates (Figure 6N).
Transcription (transcribed) of Osteocalcin in vertebral body
4) Confidence 0.22 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.05 Pain Relevance 0
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Transcription (transcripts) of osteocalcin in osteoblasts associated with metalloproteinase
5) Confidence 0.18 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
SP inhibited BN formation and ALPase activity in a dose-dependent manner (10(-7) to 10(-5) M) and further suppressed mRNA expression of bone sialoprotein, osteopontin, and osteocalcin but not of type I collagen mRNA.
Transcription (expression) of osteocalcin
6) Confidence 0.10 Published 2004 Journal J. Periodontol. Section Body Doc Link 15341355 Disease Relevance 0.07 Pain Relevance 0
During the fusion process a metaplastic shift appeared in the arch centra where cells in the intermediate zone between osteoblasts and chondrocytes co-transcribed col1a, col2a, runx2, osteocalcin and osteonectin, as visualized by ISH.
Transcription (transcribed) of osteocalcin in osteoblasts
7) Confidence 0.07 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.22 Pain Relevance 0
In these cells, low concentrations of melatonin increased the mRNA levels of several genes expressed in osteoblasts including bone sialoprotein (BSP), alkaline phosphatase (ALP), osteopontin and osteocalcin.[15] Several studies using various animal models show that melatonin prevents bone deterioration including preventing idiopathic scoliosis in adolescents[1316] and that it stimulates proliferation of normal cells such as human bone cells.[13] However, there are no reports of melatonin effects on ADSC osteogenic differentiation.
Transcription (levels) of osteocalcin in osteoblasts associated with scoliosis
8) Confidence 0.05 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.50 Pain Relevance 0.10

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