INT12114

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 46
Total Number 49
Disease Relevance 36.26
Pain Relevance 22.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 6
DRG 6
nerve 3
spinal 2
neuronal 2
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 189 100.00 Very High Very High Very High
cytokine 165 100.00 Very High Very High Very High
spinal dorsal horn 31 100.00 Very High Very High Very High
Migraine 20 99.72 Very High Very High Very High
Spinal nerve ligature 23 99.68 Very High Very High Very High
Dorsal horn 528 99.66 Very High Very High Very High
Sciatic nerve 71 99.44 Very High Very High Very High
Dorsal horn neuron 65 99.42 Very High Very High Very High
allodynia 85 99.40 Very High Very High Very High
Inflammatory response 33 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 202 100.00 Very High Very High Very High
Cancer 140 100.00 Very High Very High Very High
Necrosis 135 100.00 Very High Very High Very High
Disease 22 99.98 Very High Very High Very High
Nervous System Injury 549 99.80 Very High Very High Very High
Headache 20 99.72 Very High Very High Very High
Migraine With Aura 2 99.68 Very High Very High Very High
Metastasis 5 99.64 Very High Very High Very High
Injury 196 99.60 Very High Very High Very High
Optic Nerve Injuries 102 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat.
Positive_regulation (upregulation) of tumor necrosis factor receptors 1 in dorsal root ganglia associated with necrosis, cancer and spinal nerve ligature
1) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12875915 Disease Relevance 0.67 Pain Relevance 1.01
TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior.
Positive_regulation (upregulation) of TNFR in DRG associated with pain
2) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12875915 Disease Relevance 0.65 Pain Relevance 0.82
The spinal nerve ligature or sciatic nerve transection resulted in an increased TNFR1 IF located at the surface of the ipsilateral DRG neurons, but dispersed IF in the contralateral ones.
Positive_regulation (increased) of TNFR1 IF in sciatic nerve associated with spinal nerve ligature and sciatic nerve
3) Confidence 0.68 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.20 Pain Relevance 0.45
In contrast, the sciatic nerve ligature for 2 weeks caused a similar increase of TNFR1 IF in the neurons and their SGC of both ipsi- and contralateral DRG.
Positive_regulation (increase) of TNFR1 IF in neurons associated with sciatic nerve
4) Confidence 0.68 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.25 Pain Relevance 0.47
The sciatic and spinal nerve ligature resulted in an increased TNFR1 IF in the neuronal bodies of both ipsi- and contralateral DRG.
Positive_regulation (increased) of TNFR1 IF in neuronal associated with spinal nerve ligature
5) Confidence 0.68 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.26 Pain Relevance 0.45
These results suggest that TX14(A) decreased nociceptive behavior by attenuating both TNFR1 upregulation and Schwann cell activation in response to TNF injection.
Positive_regulation (upregulation) of TNFR1 in Schwann cell associated with nociception
6) Confidence 0.67 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.80 Pain Relevance 0.31
Interestingly, clusterin, lipocalin 2, litaf, and TNFR1a are also upregulated by other injuries as elevation of intraocular pressure (IOP) or ischemia [36-40].
Positive_regulation (upregulated) of TNFR1a associated with ischemia, injury and ocular hypertension
7) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.87 Pain Relevance 0.12
Intrathecal delivery of PDTC (8.2 ng in 10 microl volume), a nuclear factor-kappa B (NF-kappaB) inhibitor, 30 min before each rrTNF administration blocked mechanical allodynia completely and inhibited the upregulation of TNF-alpha-IR and TNFR1-IR substantially.
Positive_regulation (upregulation) of TNFR1 associated with allodynia and intrathecal
8) Confidence 0.62 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.23 Pain Relevance 0.49
Double immunofluorescence staining revealed that in DRGs the increased TNF-alpha-IR was mainly in neuronal cells and with a lesser extent in satellite glial cells, while the upregulation of TNFR1-IR was almost restricted at neuronal cells.
Positive_regulation (upregulation) of TNFR1 in neuronal
9) Confidence 0.62 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.42 Pain Relevance 0.40
The increased TNF-alpha-IR in spinal dorsal horn was observed in astrocytes, microglias and neurons, but the upregulation of TNFR1 was mainly in neurons.
Positive_regulation (upregulation) of TNFR1 in microglias associated with spinal dorsal horn
10) Confidence 0.61 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.20 Pain Relevance 0.92
These data suggest that the upregulation of TNF-alpha and TNFR1 in DRG and spinal dorsal horn is essential for the initiation but not for maintenance of the neuropathic pain induced by L5 VRT.
Positive_regulation (upregulation) of TNFR1 in DRG associated with dorsal root ganglion, spinal dorsal horn and neuropathic pain
11) Confidence 0.61 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.09 Pain Relevance 0.88
There was no change in TNFR1 mRNA levels when compared to Day 16 of pregnancy; however, there was a significant increase in TNFR1 mRNA levels from Day 22 of pregnancy to Day 3 post-partum.
Positive_regulation (increase) of TNFR1 mRNA
12) Confidence 0.61 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.30 Pain Relevance 0
Real-time RT-PCR showed a modest expression of TNFR1 mRNA in naive tissues, with a threefold increase in TNFR1 mRNA in both the ipsilateral and contralateral DRG at 3 and 7 days after induction of inflammation (Fig. 2a).
Positive_regulation (increase) of TNFR1 mRNA associated with dorsal root ganglion and inflammation
13) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.36 Pain Relevance 1.07
Interestingly, while TNFR1 activation also decreases the exocytosis of GABAARs in hippocampal neurons [26], we observed no significant effects of TNF?
Positive_regulation (activation) of TNFR1 in neurons
14) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.17 Pain Relevance 0.35
and C-fibers [30], which likely reflects the potentiation of TTX-resistant Na+ currents which occurs in DRG neurons following the activation of TNFR1 and p38 mitogen-activated protein kinase [31].
Positive_regulation (activation) of TNFR1 in neurons associated with c fibre
15) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.44 Pain Relevance 0.55
Since TNFR1 expression is also increased in dorsal horn neurons after nerve injury [12], an upregulation of TNFR1 and subsequent increase in glutamate release probability at the presynaptic terminals of excitatory interneurons may also contribute to the increased mEPSC rate.
Positive_regulation (upregulation) of TNFR1 in neurons associated with glutamate, nervous system injury and dorsal horn neuron
16) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.38 Pain Relevance 0.47
Thus, one potential explanation for the observed elevation in mEPSC frequency in the SDH is an enhanced probability of glutamate release from sensory afferents in the dorsal horn, resulting from TNFR1 upregulation within injured and/or adjacent uninjured [13] DRG neurons.
Positive_regulation (upregulation) of TNFR1 in dorsal horn associated with glutamate and dorsal horn
17) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.43 Pain Relevance 0.48
For example, the mRNAs for TNF-R1, FasL, and Nur77 are up-regulated between 2.8 and 7-fold [Mol.
Positive_regulation (up-regulated) of TNF-R1
18) Confidence 0.49 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12531535 Disease Relevance 0.17 Pain Relevance 0.08
Analyses of Western blots demonstrated a significant increase in TNF-R1 (100 and 80%) compared to the sham-controls at 2 and 24 h postinjection with NMDA.
Positive_regulation (increase) of TNF-R1
19) Confidence 0.49 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12531535 Disease Relevance 0.22 Pain Relevance 0.08
Double ISH revealed varying levels of TNFR1 mRNA in virtually all DRG neurons including putative nociceptive neurons coding for calcitonin gene-related peptide, substance P, or vanilloid receptor 1.
Positive_regulation (levels) of TNFR1 mRNA in neurons associated with nociception, dorsal root ganglion, substance p and calcitonin gene-related peptide
20) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.97 Pain Relevance 0.47

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