INT121141

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.02
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Spp1) extracellular space (Spp1) extracellular region (Spp1)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
macrophage 1
osteoblasts 1
Spp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 58 98.34 Very High Very High Very High
cytokine 12 86.80 High High
chemokine 18 76.40 Quite High
cINOD 2 65.40 Quite High
anesthesia 6 52.08 Quite High
Pain 2 50.04 Quite High
substance P 7 50.00 Quite Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 49 99.78 Very High Very High Very High
Renal Disease 2 99.38 Very High Very High Very High
Diabetes Mellitus 116 99.10 Very High Very High Very High
Hypertension 104 98.84 Very High Very High Very High
INFLAMMATION 56 98.34 Very High Very High Very High
Diabetic Nephropathy 16 98.08 Very High Very High Very High
Osteogenic Sarcomas 1 97.00 Very High Very High Very High
Osteoporosis 37 96.28 Very High Very High Very High
Adhesions 7 96.06 Very High Very High Very High
Scoliosis 1 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most prominent induction was detected for osteopontin and MCP-1.
Transcription (detected) of osteopontin
1) Confidence 0.34 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Transcription (levels) of osteopontin in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
2) Confidence 0.34 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.37 Pain Relevance 0.09
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Transcription (transcript) of osteopontin associated with hyperoxia
3) Confidence 0.21 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.36 Pain Relevance 0.19
In these cells, low concentrations of melatonin increased the mRNA levels of several genes expressed in osteoblasts including bone sialoprotein (BSP), alkaline phosphatase (ALP), osteopontin and osteocalcin.[15] Several studies using various animal models show that melatonin prevents bone deterioration including preventing idiopathic scoliosis in adolescents[1316] and that it stimulates proliferation of normal cells such as human bone cells.[13] However, there are no reports of melatonin effects on ADSC osteogenic differentiation.
Transcription (levels) of osteopontin in osteoblasts associated with scoliosis
4) Confidence 0.11 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.50 Pain Relevance 0.10
SP inhibited BN formation and ALPase activity in a dose-dependent manner (10(-7) to 10(-5) M) and further suppressed mRNA expression of bone sialoprotein, osteopontin, and osteocalcin but not of type I collagen mRNA.
Transcription (expression) of osteopontin
5) Confidence 0.09 Published 2004 Journal J. Periodontol. Section Body Doc Link 15341355 Disease Relevance 0.07 Pain Relevance 0
After 3 and 6 weeks of healing, the animals were killed and the fracture calluses examined with global gene expression, in situ mRNA expression, and ultrastructural protein distribution of four bone turnover markers: osteopontin, bone sialoprotein, tartrate-resistant acid phosphatase, and cathepsin K.
Transcription (expression) of osteopontin
6) Confidence 0.08 Published 2010 Journal Calcif Tissue Int Section Abstract Doc Link PMC2887935 Disease Relevance 0.40 Pain Relevance 0

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