INT121161

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 10.07
Pain Relevance 10.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cx3cl1) extracellular region (Cx3cl1) plasma membrane (Cx3cl1)
cytoplasm (Cx3cl1)
Anatomy Link Frequency
neurons 4
spinal 2
spinal cord 2
microglia 2
dorsal root ganglion 1
Cx3cl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 124 99.96 Very High Very High Very High
peripheral neuropathy 7 99.84 Very High Very High Very High
Inflammation 41 99.76 Very High Very High Very High
Pain 70 99.60 Very High Very High Very High
Eae 14 99.44 Very High Very High Very High
Spinal cord 37 99.08 Very High Very High Very High
chung model 2 98.96 Very High Very High Very High
Neuropathic pain 35 98.48 Very High Very High Very High
dorsal root ganglion 2 98.44 Very High Very High Very High
Spinal nerve ligature 3 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 7 99.84 Very High Very High Very High
INFLAMMATION 44 99.76 Very High Very High Very High
Disease 34 99.72 Very High Very High Very High
Pain 63 99.60 Very High Very High Very High
Injury 30 99.44 Very High Very High Very High
Infection 60 99.40 Very High Very High Very High
Nociception 24 98.50 Very High Very High Very High
Neuropathic Pain 63 98.48 Very High Very High Very High
Ganglion Cysts 3 97.96 Very High Very High Very High
Inflammatory Pain 5 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar distribution of CX3CL1 was observed after CFA, whereas after mSNL, CX3CL1 was not only observed in neurons but also found in astrocytes, as shown by colocalization of CX3CL1 and GFAP.
Localization (colocalization) of CX3CL1 in neurons
1) Confidence 0.75 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.64 Pain Relevance 0.88
In naïve rats, CX3CL1 is found in the cytoplasm of neurons as shown by colocalization of CX3XL1 and NeuN.
Localization (colocalization) of CX3CL1 in neurons
2) Confidence 0.75 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.61 Pain Relevance 0.78
Intriguingly, anti-CX3CR1 reduced nociceptive responses when administered 5-7 days after CCI, suggesting that prolonged release of fractalkine may contribute to the maintenance of neuropathic pain.
Localization (release) of fractalkine associated with nociception, eae and neuropathic pain
3) Confidence 0.62 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 1.32 Pain Relevance 1.08
As fractalkine can be released from neurons upon strong activation, it has previously been suggested to be a neuron-to-glial signal that induces glial activation.
Localization (released) of fractalkine in neuron associated with glial activation
4) Confidence 0.62 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.67 Pain Relevance 0.73
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Localization (released) of fractalkine in spinal associated with chemokine and pain
5) Confidence 0.60 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16324111 Disease Relevance 0.65 Pain Relevance 1.01
Fractalkine can be released, forming a diffusible signal.
Localization (released) of Fractalkine
6) Confidence 0.60 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.36 Pain Relevance 0.44
Taken together, these data support that neuronally released fractalkine enhances pain via activation of spinal cord glia.
Localization (released) of fractalkine in spinal cord associated with pain and spinal cord
7) Confidence 0.60 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.84 Pain Relevance 1.19
Pain enhancement occurs in response both to intrathecally administered fractalkine and to spinal fractalkine endogenously released by peripheral neuropathy.
Localization (released) of fractalkine in spinal associated with pain and peripheral neuropathy
8) Confidence 0.60 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.57 Pain Relevance 0.71
We mapped the regional and cellular localization of fractalkine and CX3CR1 in the rat spinal cord and dorsal root ganglion, under basal conditions and following induction of neuropathic pain, employing both an inflammatory (sciatic inflammatory neuropathy; SIN) as well as a traumatic (chronic constriction injury; CCI) model.
Localization (localization) of fractalkine in spinal cord associated with ganglion cysts, dorsal root ganglion, inflammation, eae, injury, neuropathic pain and spinal cord
9) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 1.03 Pain Relevance 0.90
Although constitutively expressed and released during inflammation, increased release of fractalkine binds to and activates microglia leading to pathological pain.
Localization (release) of fractalkine in microglia associated with pain and inflammation
10) Confidence 0.51 Published 2008 Journal J. Neuroimmunol. Section Abstract Doc Link 18547654 Disease Relevance 0.90 Pain Relevance 0.75
Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.
Localization (released) of CX3CL1 in microglia associated with metalloproteinase, disease and infection
11) Confidence 0.35 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.52 Pain Relevance 0.15
We mapped the regional and cellular localization of fractalkine and CX3CR1 in the rat spinal cord and dorsal root ganglion, under basal conditions and following induction of neuropathic pain, employing both an inflammatory (sciatic inflammatory neuropathy; SIN) as well as a traumatic (chronic constriction injury; CCI) model.
Localization (localization) of fractalkine in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, inflammation, eae, injury, neuropathic pain and spinal cord
12) Confidence 0.20 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 1.03 Pain Relevance 0.90
Neuronal expression of IP-10/CXCR3 under basal conditions may have a specific role to play that is analogous to the expression and release of fractalkine by neurons [42,55].
Localization (release) of fractalkine in neurons
13) Confidence 0.19 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.57 Pain Relevance 0.69
Potential signals may include central release of fractalkine or other growth factors [28].
Localization (release) of fractalkine
14) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.37 Pain Relevance 0.40

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