INT121162

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 11.56
Pain Relevance 14.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cx3cl1) extracellular region (Cx3cl1) plasma membrane (Cx3cl1)
cytoplasm (Cx3cl1)
Anatomy Link Frequency
neurons 7
spinal cord 5
microglia 4
spinal 3
intrinsic neurons 2
Cx3cl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 139 100.00 Very High Very High Very High
Spinal cord 64 99.96 Very High Very High Very High
Inflammation 48 99.74 Very High Very High Very High
neuralgia 15 99.74 Very High Very High Very High
Dorsal horn 12 99.64 Very High Very High Very High
glial activation 18 99.44 Very High Very High Very High
Neuritis 3 97.64 Very High Very High Very High
IPN 13 97.48 Very High Very High Very High
Neuropathic pain 52 96.96 Very High Very High Very High
Lasting pain 15 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 99.68 Very High Very High Very High
Immunization 4 99.14 Very High Very High Very High
Nervous System Injury 42 99.02 Very High Very High Very High
Experimental Autoimmune Neuritis 3 97.64 Very High Very High Very High
Inflammatory Pain 16 97.48 Very High Very High Very High
Nociception 37 97.04 Very High Very High Very High
Neuropathic Pain 99 96.96 Very High Very High Very High
Pain 53 96.60 Very High Very High Very High
Hyperalgesia 45 93.96 High High
Injury 39 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain.
Gene_expression (expression) of CX3CL1 in astrocytes associated with inflammation, neuropathic pain and spinal cord
1) Confidence 0.78 Published 2005 Journal J Pain Section Title Doc Link 15993821 Disease Relevance 0.58 Pain Relevance 1.06
These beneficial effects of GA immunization therapy coincided with the attenuation of expression of the chemotactic fractalkine chemokine (CX3CL1) in the dorsal horn of the lumbar spinal cord (L4-L5) in response to CFA treatment, assessed by DNA microarray and confirmed immunocytochemically (ICC).
Gene_expression (expression) of CX3CL1 in spinal cord associated with chemokine, immunization, dorsal horn and spinal cord
2) Confidence 0.78 Published 2008 Journal Int. J. Neurosci. Section Abstract Doc Link 18300014 Disease Relevance 0.86 Pain Relevance 0.85
Fractalkine (CX3C ligand-1; CX3CL1) is a unique chemokine expressed on the extracellular surface of spinal neurons and spinal sensory afferents.
Gene_expression (expressed) of CX3CL1 in neurons associated with chemokine
3) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.36 Pain Relevance 0.47
Spinal fractalkine (CX3CL1) is expressed by sensory afferents and intrinsic neurons, whereas its receptor (CX3CR1) is predominantly expressed by microglia.
Gene_expression (expressed) of CX3CL1 in intrinsic neurons
4) Confidence 0.76 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.38 Pain Relevance 0.48
Spinal fractalkine (CX3CL1) is expressed by sensory afferents and intrinsic neurons, whereas its receptor (CX3CR1) is predominantly expressed by microglia.
Gene_expression (expressed) of fractalkine in intrinsic neurons
5) Confidence 0.76 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.38 Pain Relevance 0.48
Fractalkine (CX3C ligand-1; CX3CL1) is a unique chemokine expressed on the extracellular surface of spinal neurons and spinal sensory afferents.
Gene_expression (expressed) of CX3C in neurons associated with chemokine
6) Confidence 0.75 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.36 Pain Relevance 0.47
These beneficial effects of GA immunization therapy coincided with the attenuation of expression of the chemotactic fractalkine chemokine (CX3CL1) in the dorsal horn of the lumbar spinal cord (L4-L5) in response to CFA treatment, assessed by DNA microarray and confirmed immunocytochemically (ICC).
Gene_expression (expression) of chemotactic fractalkine chemokine in spinal cord associated with chemokine, immunization, dorsal horn and spinal cord
7) Confidence 0.68 Published 2008 Journal Int. J. Neurosci. Section Abstract Doc Link 18300014 Disease Relevance 0.85 Pain Relevance 0.84
Fractalkine (CX3C ligand-1; CX3CL1) is a unique chemokine expressed on the extracellular surface of spinal neurons and spinal sensory afferents.
Gene_expression (expressed) of Fractalkine in neurons associated with chemokine
8) Confidence 0.68 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.36 Pain Relevance 0.47
In the dorsal spinal cord, fractalkine receptors are primarily expressed by microglia.
Gene_expression (expressed) of fractalkine in microglia associated with spinal cord
9) Confidence 0.68 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.55 Pain Relevance 0.66
The purpose of this study was to provide an immunohistochemical description of the distribution of CX3CL1 (fractalkine) and its receptor CX3CR1 in the rat spinal cord in a model of inflammatory pain induced by unilateral intraplantar complete Freund's adjuvant (CFA) and in a model of neuropathic pain induced by L5 spinal nerve ligation (modified Chung model or mSNL).
Gene_expression (distribution) of CX3CL1 in spinal cord associated with spinal nerve ligature, ipn, chung model, neuropathic pain and spinal cord
10) Confidence 0.68 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.36 Pain Relevance 0.63
Similar distribution of CX3CL1 was observed after CFA, whereas after mSNL, CX3CL1 was not only observed in neurons but also found in astrocytes, as shown by colocalization of CX3CL1 and GFAP.
Gene_expression (observed) of CX3CL1 in neurons
11) Confidence 0.68 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.63 Pain Relevance 0.80
Similar distribution of CX3CL1 was observed after CFA, whereas after mSNL, CX3CL1 was not only observed in neurons but also found in astrocytes, as shown by colocalization of CX3CL1 and GFAP.
Gene_expression (distribution) of CX3CL1 in neurons
12) Confidence 0.68 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.61 Pain Relevance 0.80
The purpose of this study was to provide an immunohistochemical description of the distribution of CX3CL1 (fractalkine) and its receptor CX3CR1 in the rat spinal cord in a model of inflammatory pain induced by unilateral intraplantar complete Freund's adjuvant (CFA) and in a model of neuropathic pain induced by L5 spinal nerve ligation (modified Chung model or mSNL).
Gene_expression (distribution) of fractalkine in spinal cord associated with spinal nerve ligature, ipn, chung model, neuropathic pain and spinal cord
13) Confidence 0.59 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.36 Pain Relevance 0.63
The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.
Gene_expression (expression) of CX3CL1 in microglia associated with pain, chemokine and neuritis
14) Confidence 0.58 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18448252 Disease Relevance 1.05 Pain Relevance 0.88
Little is known about the expression of fractalkine and CX3CR1 in spinal cord.
Gene_expression (expression) of fractalkine in spinal cord associated with spinal cord
15) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.50 Pain Relevance 0.62
PERSPECTIVE: This study shows that spinal nerve injury, but not peripheral inflammation, induces the expression of a chemokine, CX3CL1 (fractalkine), in astrocytes and upregulates CX3CR1 in microglia in the spinal cord.
Gene_expression (pression o) of fractalkine in microglia associated with chemokine, nervous system injury, inflammation and spinal cord
16) Confidence 0.53 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.66 Pain Relevance 0.90
PERSPECTIVE: This study shows that spinal nerve injury, but not peripheral inflammation, induces the expression of a chemokine, CX3CL1 (fractalkine), in astrocytes and upregulates CX3CR1 in microglia in the spinal cord.
Gene_expression (pression o) of CX3CL1 in microglia associated with chemokine, nervous system injury, inflammation and spinal cord
17) Confidence 0.53 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.66 Pain Relevance 0.89
Fractalkine is a unique chemokine reported to be constitutively expressed by neurons.
Gene_expression (expressed) of Fractalkine in neurons associated with chemokine
18) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.41 Pain Relevance 0.53
Fractalkine (CX3C ligand-1; CX3CL1) is a unique chemokine expressed on the extracellular surface of spinal neurons and spinal sensory afferents.
Gene_expression (expressed) of CX3CL1 in spinal associated with chemokine
19) Confidence 0.26 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.36 Pain Relevance 0.47
Fractalkine (CX3C ligand-1; CX3CL1) is a unique chemokine expressed on the extracellular surface of spinal neurons and spinal sensory afferents.
Gene_expression (expressed) of CX3C in spinal associated with chemokine
20) Confidence 0.26 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525271 Disease Relevance 0.36 Pain Relevance 0.47

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