INT12117

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 1996
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.49
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
digastric 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 36 100.00 Very High Very High Very High
opiate 18 100.00 Very High Very High Very High
agonist 11 98.64 Very High Very High Very High
Opioid 3 98.48 Very High Very High Very High
antagonist 2 96.52 Very High Very High Very High
Endogenous opioid 3 94.08 High High
Kappa opioid receptor 3 75.00 Quite High
Potency 1 72.72 Quite High
opioid receptor 3 52.16 Quite High
tolerance 1 41.92 Quite Low
Disease Link Frequency Relevance Heat
Eating Disorder 6 99.08 Very High Very High Very High
Diabetes Mellitus 4 97.56 Very High Very High Very High
Diabetes Mellitus-type I 3 96.88 Very High Very High Very High
Chronic Renal Failure 9 96.44 Very High Very High Very High
Renal Disease 5 87.88 High High
Reprotox - General 1 3 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The desensitization of the kappa receptor is dependent on the time and concentration of agonist treatment, is blocked by the kappa-selective antagonist nor-binaltorphimine and is reversible.
Regulation (dependent) of Negative_regulation (desensitization) of kappa receptor associated with antagonist and agonist
1) Confidence 0.44 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.77
Effects of opiate receptor blockade on gonadotrophin secretion before and after administration of the oestrogen receptor blocker tamoxifen in eugonadal men.
Regulation (Effects) of Negative_regulation (blockade) of opiate receptor associated with narcan and opiate
2) Confidence 0.03 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2854762 Disease Relevance 0 Pain Relevance 0.45
Opiate-receptor blockade did not alter VAS inhibition of the DGR and, thus, opioids are not likely to mediate VAS-induced digastric inhibition.
Neg (not) Regulation (alter) of Negative_regulation (blockade) of Opiate-receptor in digastric associated with opiate and opioid
3) Confidence 0.02 Published 1992 Journal Brain Res. Section Abstract Doc Link 1628214 Disease Relevance 0 Pain Relevance 0.26
[Effects of opiate receptor blockade with naloxone on prolactin (PRL) secretion in patients with diabetes type I (IDDM) with chronic renal failure treated with hemodialysis (HD)].
Regulation (Effects) of Negative_regulation (blockade) of opiate receptor associated with diabetes mellitus-type i, chronic renal failure, diabetes mellitus, narcan and opiate
4) Confidence 0.01 Published 1996 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 9122001 Disease Relevance 1.22 Pain Relevance 0.32
Because there was no additional effect of opiate receptor blockade after oestrogen receptor blockade on pulsatile LH secretion we infer that androgens may be impeded in their negative feedback action in the presence of the antioestrogen tamoxifen.
Neg (no) Regulation (effect) of Negative_regulation (blockade) of opiate receptor associated with opiate
5) Confidence 0.01 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2854762 Disease Relevance 0 Pain Relevance 0.45
For this purpose the effect of opiate receptor blockade with naloxone on LH, FSH, PRL, and beta-endorphins secretion was studied in 24 women with anorexia nervosa and 7 normal women.
Regulation (effect) of Negative_regulation (blockade) of opiate receptor associated with narcan, opiate and eating disorder
6) Confidence 0.01 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6086696 Disease Relevance 0.27 Pain Relevance 0.57

General Comments

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