INT121170

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.32
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
brain 6
bladder 4
neuronal 2
cholinergic neurons 2
Nerve 2
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 35 98.92 Very High Very High Very High
Paracetamol 3 98.84 Very High Very High Very High
Neuropathic pain 4 98.64 Very High Very High Very High
aspirin 3 98.48 Very High Very High Very High
Inflammation 48 96.32 Very High Very High Very High
Analgesic 3 95.52 Very High Very High Very High
Central nervous system 30 88.32 High High
Kinase C 27 80.96 Quite High
TRP channel 1 80.40 Quite High
dorsal root ganglion 3 77.12 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 3 99.98 Very High Very High Very High
Cancer 22 99.96 Very High Very High Very High
Drug Induced Neurotoxicity 20 99.92 Very High Very High Very High
Brain Injury 5 99.90 Very High Very High Very High
Bladder Cancer 6 99.80 Very High Very High Very High
Disease 635 99.78 Very High Very High Very High
Neurodegenerative Disease 184 99.36 Very High Very High Very High
Aging 25 99.34 Very High Very High Very High
Death 292 99.00 Very High Very High Very High
Neuropathic Pain 4 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve injury increased the expression and axonal transport of p75NTR and phosphorylation of TrkA in the uninjured primary afferents.
Positive_regulation (increased) of Gene_expression (expression) of p75NTR in Nerve associated with nervous system injury
1) Confidence 0.64 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 0.96 Pain Relevance 0.57
We observed that NSAID treatment of cell lines from bladder and other organs induced expression of the p75NTR protein.
Positive_regulation (induced) of Gene_expression (expression) of p75NTR in bladder associated with cinod
2) Confidence 0.33 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.84 Pain Relevance 1.00
Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein.
Positive_regulation (induced) of Gene_expression (expression) of p75NTR in bladder associated with cancer and bladder cancer
3) Confidence 0.33 Published 2004 Journal Cancer Res. Section Title Doc Link 15342406 Disease Relevance 0.83 Pain Relevance 0.95
Of the different types of NSAIDs examined, ibuprofen was more efficacious than aspirin and acetaminophen and comparable with (R)-flurbiprofen and indomethacin in induction of p75NTR protein expression.
Positive_regulation (induction) of Gene_expression (expression) of p75NTR associated with aspirin, paracetamol and cinod
4) Confidence 0.33 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.85 Pain Relevance 1.02
Reduced expression of neurotrophins181,210 together with reduced expression and activation of Trk and concomitant increased expression of p75NTR indicate that the possible consequence is a tipping of the balance away from cell survival, which could be associated with structural abnormalities and reduced neuronal plasticity in suicide brain specimens.
Positive_regulation (increased) of Gene_expression (expression) of p75NTR in brain associated with suicidal behaviour and congenital anomalies
5) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.69 Pain Relevance 0.06
Recently, we observed that the expression ratio of p75NTR to Trk receptors is increased in the postmortem brain specimens of suicide subjects.
Positive_regulation (increased) of Gene_expression (expression) of p75NTR in brain associated with suicidal behaviour
6) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.70 Pain Relevance 0.04
In general, NF-kB is regarded as an anti-apoptotic transcription factor and its activation is believed to be fundamental in neuroprotection and repair following brain injury and upregulation of p75 expression.
Positive_regulation (upregulation) of Gene_expression (expression) of p75 in brain associated with apoptosis and brain injury
7) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.64 Pain Relevance 0.03
is a another key trigger of neuronal apoptosis in AD and its neurotoxicity is enhanced by expression of the p75 receptor.
Positive_regulation (enhanced) of Gene_expression (expression) of p75 receptor in neuronal associated with drug induced neurotoxicity, disease and neurodegenerative disease
8) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.46 Pain Relevance 0
in aging might depend on a switch of TrkA-p75 expression and that p75 enhances A?
Positive_regulation (-) of Gene_expression (expression) of p75 associated with aging
9) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0.11
In AD patients, increased p75 expression [95] is accompanied by a 50% reduction in TrkA levels [96], thus providing a challenging interpretation for decreased NGF survival signaling and increased p75-induced apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of p75 associated with apoptosis and disease
10) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.32 Pain Relevance 0.16
Moreover, overexpression of p75 contributes to neuronal death of cholinergic neurons [93].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p75 in cholinergic neurons associated with death
11) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.67 Pain Relevance 0

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