INT121171

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.46
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
nerve 3
sciatic nerve 2
bladder 2
sensory neurons 1
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
neuralgia 3 100.00 Very High Very High Very High
Sciatic nerve 8 99.98 Very High Very High Very High
Neuropathic pain 4 99.96 Very High Very High Very High
Pain 11 99.80 Very High Very High Very High
cINOD 11 98.92 Very High Very High Very High
Inflammation 10 96.32 Very High Very High Very High
Analgesic 1 95.52 Very High Very High Very High
allodynia 6 89.36 High High
Kinase C 5 80.96 Quite High
Disease Link Frequency Relevance Heat
Bladder Cancer 2 100.00 Very High Very High Very High
Cancer 10 99.96 Very High Very High Very High
Neuropathic Pain 10 99.96 Very High Very High Very High
Pain 9 99.80 Very High Very High Very High
Aging 6 99.62 Very High Very High Very High
Nervous System Injury 3 99.04 Very High Very High Very High
INFLAMMATION 15 98.20 Very High Very High Very High
Apoptosis 208 97.68 Very High Very High Very High
Death 75 93.88 High High
Ganglion Cysts 5 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of the p75 NTR inhibitory antibody to the pinched sciatic nerve suppressed CGRP and p75 NTR expression and pain behavior.
Negative_regulation (suppressed) of Gene_expression (expression) of p75 in sciatic nerve associated with pain, sciatic nerve and calcitonin gene-related peptide
1) Confidence 0.58 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.60 Pain Relevance 0.98
CGRP and p75 NTR immunoreactivity in the L5 DRG neurons was upregulated in the injured nerve groups compared with the sham-operated group; however, p75 NTR inhibitory antibody decreased the CGRP and p75 NTR expression (p < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of p75 in nerve associated with calcitonin gene-related peptide
2) Confidence 0.58 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.53 Pain Relevance 1.01
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
Negative_regulation (reduces) of in nerve Gene_expression (Suppression) of p75 neurotrophin receptor in sensory neurons associated with neuralgia, nervous system injury and neuropathic pain
3) Confidence 0.39 Published 2006 Journal J. Neurosci. Section Title Doc Link 17108171 Disease Relevance 0.91 Pain Relevance 0.84
Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein.
Negative_regulation (inhibits) of Gene_expression (expression) of p75NTR in bladder associated with cancer and bladder cancer
4) Confidence 0.20 Published 2004 Journal Cancer Res. Section Title Doc Link 15342406 Disease Relevance 0.83 Pain Relevance 0.95
in aging might depend on a switch of TrkA-p75 expression and that p75 enhances A?
Negative_regulation (switch) of Gene_expression (expression) of p75 associated with aging
5) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0.11
Our previous data also showed that estrogen decreased the expression of another member of the Fas family, the pan-neurotrophin receptor p75NTR [48,49].
Negative_regulation (decreased) of Gene_expression (expression) of pan-neurotrophin receptor p75NTR
6) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0

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