INT121189

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
KCNMA1 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 24 100.00 Very High Very High Very High
antagonist 4 97.68 Very High Very High Very High
Pain 2 75.00 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 2 88.56 High High
Osteoporosis 4 78.40 Quite High
Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, both SB203580 (an inhibitor of p38 mitogen-activated protein kinase [MAPK]) and PD98059 (an inhibitor of MEK, upstream of ERK) attenuated the BK-induced IL-6 and PGE(2) synthesis.
BK Positive_regulation (induced) of IL-6 associated with bradykinin
1) Confidence 0.04 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.30 Pain Relevance 0.62
U-73122, a phospholipase C (PLC) inhibitor, suppressed BK-induced IL-6 and PGE(2) synthesis in SaM-1 cells.
BK Positive_regulation (induced) of IL-6 associated with bradykinin
2) Confidence 0.03 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.24 Pain Relevance 0.61

General Comments

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