INT1212

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Context Info
Confidence 0.48
First Reported 1973
Last Reported 2010
Negated 9
Speculated 19
Reported most in Abstract
Documents 312
Total Number 332
Disease Relevance 28.60
Pain Relevance 225.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 45
spinal cord 10
CNS 6
NG108-15 5
striatum 5
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 819 100.00 Very High Very High Very High
Morphine 520 100.00 Very High Very High Very High
Opioid 308 100.00 Very High Very High Very High
narcan 304 100.00 Very High Very High Very High
Enkephalin 302 100.00 Very High Very High Very High
orphanin 277 100.00 Very High Very High Very High
agonist 235 100.00 Very High Very High Very High
Buprenorphine 218 100.00 Very High Very High Very High
opioid receptor 216 100.00 Very High Very High Very High
antagonist 185 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 10 99.92 Very High Very High Very High
Injury 35 99.84 Very High Very High Very High
Pain 75 99.80 Very High Very High Very High
Hyperalgesia 21 99.78 Very High Very High Very High
Nociception 24 99.74 Very High Very High Very High
Urological Neuroanatomy 26 99.68 Very High Very High Very High
Opiate Addiction 16 99.60 Very High Very High Very High
Sleep Disorders 7 99.56 Very High Very High Very High
Erectile Dysfunction 3 99.54 Very High Very High Very High
Spinal Injuries 6 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ORL-1 does not bind any of the classical opioids, although a high affinity endogenous agonist with close homology to dynorphin has recently been identified.
ORL-1 Neg (not) Binding (bind) of associated with dynorphin, agonist and opioid
1) Confidence 0.48 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8725304 Disease Relevance 0 Pain Relevance 0.43
Butorphanol is a mixed agonist/antagonist opioid analgesic agent, which exerts its effects mainly by interaction with the kappa-opioid receptor.
kappa-opioid receptor Binding (interaction) of associated with analgesic, antagonist, kappa opioid receptor, agonist, butorphanol and opioid
2) Confidence 0.48 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10779697 Disease Relevance 0 Pain Relevance 1.08
Opiate receptor binding in the brain of the hypertensive rat.
Opiate receptor Binding (binding) of in brain associated with hypertension and opiate
3) Confidence 0.48 Published 1981 Journal Brain Res. Section Title Doc Link 6263410 Disease Relevance 0.36 Pain Relevance 0.66
In conclusion, while the steady-state spinal dynorphin release is low in morphine-dependent rats, it can be activated by 100-Hz EA stimulation, which may be responsible for eliciting an analgesic effect and ameliorating morphine withdrawal syndrome, most probably via interacting with kappa-opioid receptor at spinal level.
kappa-opioid receptor Binding (interacting) of in spinal associated with dynorphin, analgesic, kappa opioid receptor, withdrawal, electroacupuncture and morphine
4) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10642860 Disease Relevance 0.18 Pain Relevance 1.76
The increased tissue cAMP concentrations associated with the altered physiology of heroin administration apparently represent a pattern of integrated responses to the combination of opiate receptor binding and effects on neurotransmitter metabolism and circulating hormones.
opiate receptor Binding (binding) of associated with neurotransmitter and opiate
5) Confidence 0.48 Published 1976 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 176669 Disease Relevance 0 Pain Relevance 0.36
It is concluded that the slice is the preferable preparation for the in vitro estimation of opiate receptor binding and that chronic morphine treatment alters the binding of morphine to brainstem.
opiate receptor Binding (binding) of in brainstem associated with medulla, opiate and morphine
6) Confidence 0.48 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197922 Disease Relevance 0 Pain Relevance 1.72
Significantly, the opiate receptor binding seen in the transplants was never organized into the dense patches normally seen in the adult striatum.
opiate receptor Binding (binding) of in striatum associated with opiate
7) Confidence 0.48 Published 1986 Journal Brain Res. Section Abstract Doc Link 3011213 Disease Relevance 0 Pain Relevance 0.52
Total opioid peptide activity was assayed by the ability of brain extracts to compete for opiate receptor binding.
opiate receptor Binding (binding) of in brain associated with opiate and opioid
8) Confidence 0.48 Published 1977 Journal Eur. J. Pharmacol. Section Abstract Doc Link 563332 Disease Relevance 0 Pain Relevance 1.12
Alterations in nociceptive reactivity, opiate receptor binding, and other behavioral responses occur in rats exposed to morphine either in utero or post-natally.
opiate receptor Binding (binding) of associated with nociception, opiate and morphine
9) Confidence 0.48 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2505292 Disease Relevance 0.36 Pain Relevance 0.84
The endogenous concentrations of zinc ions in the hippocampus, the cerebral cortex and the basal ganglia are compatible with the concentrations needed to inhibit opiate receptor binding in vitro.
opiate receptor Binding (binding) of in basal ganglia associated with opiate, hippocampus and cerebral cortex
10) Confidence 0.48 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.84
Based on these and previous results, a proposal is made for the interaction of the orvinols with the opiate receptor involving both lipophilic (L) and hydrophilic (H) subsites.
opiate receptor Binding (interaction) of associated with opiate
11) Confidence 0.48 Published 1984 Journal J. Med. Chem. Section Abstract Doc Link 6708052 Disease Relevance 0 Pain Relevance 0.41
Since antidepressants exert their own analgesic effect, increase morphine analgesia and displace opiate receptor binding, it may be that by interacting with the opiate receptor complex imipramine induces supersensitivity in opiate recognition binding sites.
opiate receptor Binding (interacting) of associated with antidepressant, analgesic, opiate, analgesia and morphine
12) Confidence 0.48 Published 1983 Journal Pharmacol Res Commun Section Abstract Doc Link 6647527 Disease Relevance 0.08 Pain Relevance 1.45
These results suggest that nalbuphine's beneficial effects in hemorrhagic shock depend on an intact sympathoadrenal system and on an interaction with opiate receptor sites, possibly in the heart.
opiate receptor Binding (interaction) of in heart associated with nalbuphine, opiate and hemorrhagic shock
13) Confidence 0.48 Published 1988 Journal Circ. Shock Section Abstract Doc Link 2847883 Disease Relevance 0.54 Pain Relevance 1.21
Since antidepressants exert their own analgesic effect, increase morphine analgesia and displace opiate receptor binding, it may be that by interacting with the opiate receptor complex imipramine induces supersensitivity in opiate recognition binding sites.
opiate receptor Binding (binding) of associated with antidepressant, analgesic, opiate, analgesia and morphine
14) Confidence 0.48 Published 1983 Journal Pharmacol Res Commun Section Abstract Doc Link 6647527 Disease Relevance 0.08 Pain Relevance 1.47
Hence, zinc ions may represent important modulators of opiate receptor binding in the central nervous system, particularly in the hippocampal mossy fiber zone.
opiate receptor Binding (binding) of in mossy fiber associated with central nervous system and opiate
15) Confidence 0.48 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.82
An in vivo autoradiographic technique permitted the visualization of discrete neuroanatomical changes in opiate receptor binding as a result of 23-h water deprivation and drinking.
opiate receptor Binding (binding) of associated with opiate
16) Confidence 0.48 Published 1987 Journal Brain Res. Section Abstract Doc Link 3036314 Disease Relevance 0 Pain Relevance 0.17
The effect of the divalent cations, Mn2+, Mg2+ and Ca2+ on rat forebrain delta-, mu- and kappa-receptor binding was examined during postnatal development.
kappa-receptor Binding (binding) of in forebrain
17) Confidence 0.48 Published 1987 Journal Brain Res. Section Abstract Doc Link 3030506 Disease Relevance 0 Pain Relevance 0.21
Differential ontogeny of divalent cation effects on rat brain delta-, mu-, and kappa-opioid receptor binding.
kappa-opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and enkephalin
18) Confidence 0.48 Published 1987 Journal Brain Res. Section Title Doc Link 3030506 Disease Relevance 0 Pain Relevance 0.33
It was investigated whether there is an endogenous factor in the brain which binds to the opiate receptor in neural tissue.
opiate receptor Binding (binds) of in neural associated with opiate
19) Confidence 0.48 Published 1975 Journal Acta Physiol. Scand. Section Abstract Doc Link 1155169 Disease Relevance 0 Pain Relevance 0.17
The factor inhibited binding to the opiate receptor in synaptic plasma membranes of rat brain and to the receptor of the guinea-pig ileum although it was less effective on the latter, particularly after long-term incubation.
opiate receptor Binding (binding) of in ileum associated with opiate
20) Confidence 0.48 Published 1975 Journal Acta Physiol. Scand. Section Abstract Doc Link 1155169 Disease Relevance 0 Pain Relevance 0.25

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