INT121207

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.35
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 8
DRG 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 1 92.96 High High
hypoalgesia 1 88.20 High High
chemokine 50 86.72 High High
cytokine 96 86.24 High High
peripheral neuropathy 1 85.96 High High
Peripheral nervous system 1 82.16 Quite High
agonist 20 75.08 Quite High
tolerance 92 67.52 Quite High
Eae 1 35.56 Quite Low
Inflammation 49 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 90 99.68 Very High Very High Very High
Aging 497 99.46 Very High Very High Very High
Obesity 677 98.76 Very High Very High Very High
Cancer 844 95.92 Very High Very High Very High
Metastasis 460 94.88 High High
Hyperalgesia 1 92.96 High High
Death 90 92.08 High High
Diabetes Mellitus 25 88.68 High High
Hypoalagesia 1 88.20 High High
Peripheral Neuropathy 2 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of Stat3 in nucleus
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12
Western blotting experiments revealed attenuation of neurofilament hyperphosphorylation, up-regulation of beta-tubulin and actin, and increased phosphorylation of the transcription factor STAT3 in DRG.
Negative_regulation (attenuation) of Phosphorylation (phosphorylation) of STAT3 in DRG
2) Confidence 0.38 Published 2004 Journal FASEB J. Section Abstract Doc Link 15345684 Disease Relevance 0.59 Pain Relevance 0.30
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Stat3 associated with skin cancer
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.59 Pain Relevance 0.04
In contrast, activation of TLR4 inhibited the expression and phosphorylation of Stat3 (Fig. 2A–D).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Stat3
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.25 Pain Relevance 0.20
In turn, the anti-IL-6 plus IL-10 Abs partially inhibited the Pam3Cys-stimulated expression, phosphorylation and nucleus translocation of Stat3 (Fig. 2D–F).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Stat3 in nucleus
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.15 Pain Relevance 0
TLR2 KD not only markedly blocked the Pam3Cys-stimulated expression and phosphorylation of Stat3, but also significantly reduced the constitutive expression and phosphorylation of Stat3 compared to the basal level of Stat3 in B16 cells (P<0.001, Fig. 2C), suggesting the basal activity of TLR2 is critical for the constitutive activation of Stat3 in the tumor cells.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Stat3 associated with cancer
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.27 Pain Relevance 0.19
Similar to the IL-6- plus IL-10- neutralizing Ab, the TLR2 shRNA markedly inhibited the expression, phosphorylation and nucleus translocation of Stat3, which were partially restored by rmIL-6 and rmIL-10 (Fig. 2D–F).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Stat3 in nucleus
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.16 Pain Relevance 0
Knockdown of TLR2 significantly attenuated the HSP60-stimulated expressions of VEGF (P<0.01), IL-10 (P<0.01), and the phosphorylation of Stat3 (P<0.01) (Fig.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of Stat3
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.71 Pain Relevance 0.03
TLR2 KD not only markedly blocked the Pam3Cys-stimulated expression and phosphorylation of Stat3, but also significantly reduced the constitutive expression and phosphorylation of Stat3 compared to the basal level of Stat3 in B16 cells (P<0.001, Fig. 2C), suggesting the basal activity of TLR2 is critical for the constitutive activation of Stat3 in the tumor cells.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Stat3 associated with cancer
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.27 Pain Relevance 0.18
TLR2 KD not only markedly blocked the Pam3Cys-stimulated expression and phosphorylation of Stat3, but also significantly reduced the constitutive expression and phosphorylation of Stat3 compared to the basal level of Stat3 in B16 cells (P<0.001, Fig. 2C), suggesting the basal activity of TLR2 is critical for the constitutive activation of Stat3 in the tumor cells.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Stat3 associated with cancer
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.27 Pain Relevance 0.19
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of Stat3 in nucleus
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12
Our further observation in Ob-R expression and
               STAT-3 phosphorylation depicted reduced Ob-R expression and STAT-3 phosphorylation
               in both ob/ob age groups. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of STAT-3
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.64 Pain Relevance 0
Our further observation in Ob-R expression and
               STAT-3 phosphorylation depicted reduced Ob-R expression and STAT-3 phosphorylation
               in both ob/ob age groups. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of STAT-3
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.58 Pain Relevance 0
Our results shown in Fig. 6 revealed that obesity,
                   but not aging (12-month), significantly reduced Ob-R protein expression and its
                   post-receptor signaling STAT-3 phosphorylation without affecting the total
                   STAT-3 expression. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.91 Pain Relevance 0
Western blot analysis exhibited reduced
                       Ob-R expression and STAT-3 phosphorylation in both young and aging
                           ob/ob mice, which was restored by leptin. 
Negative_regulation (exhibited) of Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.95 Pain Relevance 0
In similar fashion, HDAC3 is involved in inhibition of STAT3 phosphorylation [62].
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of STAT3
16) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.33 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox