INT121218

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Arrb2, Prkca) nucleus (Arrb2, Prkca) plasma membrane (Arrb2, Prkca)
mitochondrion (Prkca) transport (Arrb2) endoplasmic reticulum (Prkca)
Arrb2 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 7 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
tolerance 11 99.96 Very High Very High Very High
Opioid 9 99.76 Very High Very High Very High
nMDA receptor 2 99.04 Very High Very High Very High
Morphine 3 84.48 Quite High
Antinociceptive 1 83.28 Quite High
Glutamate 2 75.00 Quite High
nMDA receptor antagonist 1 62.92 Quite High
Pain 1 61.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 89.56 High High
Pain 2 61.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, PKC is regulated by NMDA receptors to affect the development of opioid tolerance, beta-arrestin-2 also influences PKC-induced opioid receptor desensitization.
beta-arrestin-2 Regulation (influences) of Negative_regulation (desensitization) of PKC-induced associated with kinase c, nmda receptor, tolerance, opioid receptor and opioid
1) Confidence 0.17 Published 2004 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 15346705 Disease Relevance 0.23 Pain Relevance 1.80

General Comments

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