INT121223

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Context Info
Confidence 0.16
First Reported 2001
Last Reported 2010
Negated 7
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 4.52
Pain Relevance 12.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
nerve 2
DRG 2
stem 2
mast cells 2
mononuclear phagocytes 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 2506 100.00 Very High Very High Very High
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
Nerve growth factor 68 99.96 Very High Very High Very High
dorsal root ganglion 5 99.68 Very High Very High Very High
allodynia 46 98.60 Very High Very High Very High
Trk A 12 97.70 Very High Very High Very High
Inflammation 186 97.40 Very High Very High Very High
Neuropeptide 51 94.80 High High
bradykinin 2 90.56 High High
Crohn's disease 25 90.00 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.20 Very High Very High Very High
Inflammatory Bowel Disease 98 99.16 Very High Very High Very High
Neuropathic Pain 57 98.60 Very High Very High Very High
INFLAMMATION 189 97.40 Very High Very High Very High
Nociception 30 93.96 High High
Disease 42 90.00 High High
Diabetes Mellitus 47 89.52 High High
Depression 23 89.00 High High
Infection 4 85.84 High High
Diabetic Neuropathy 38 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that NGF, SP, and calcitonin gene-related peptide gene expression is upregulated in the dorsal root ganglion (DRG) of db/db mice before or during the period that they develop mechanical allodynia.
Positive_regulation (upregulated) of Gene_expression (expression) of SP in DRG associated with ganglion cysts, dorsal root ganglion, allodynia, nerve growth factor and calcitonin gene-related peptide
1) Confidence 0.16 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19816194 Disease Relevance 1.26 Pain Relevance 1.09
RESULTS: NGF injected into the lower airway was able to induce SP (13.0+/-2.03% vs. 5.9+/-0.33%) and trkA expression (78+/-2.66% vs. 60+/-2.11%) in larger diameter (>25 microm), capsaicin-insensitive and trkA-positive vagal sensory neurons that were retrograde-labelled with Fast Blue dye from the main stem bronchi.
Positive_regulation (induce) of Gene_expression (expression) of SP in stem
2) Confidence 0.14 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [36].
Positive_regulation (promote) of Gene_expression (expression) of SP associated with nerve growth factor, trk a and substance p
3) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.66 Pain Relevance 1.11
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (tested) of Neg (nor) Gene_expression (nor) of SP associated with substance p
4) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.80
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (concentration) of Neg (nor) Gene_expression (nor) of SP associated with substance p
5) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.81
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (-) of Neg (nor) Gene_expression (nor) of tetramethylrhodamine-SP associated with substance p
6) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.79
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (concentration) of Neg (nor) Gene_expression (nor) of tetramethylrhodamine-SP associated with substance p
7) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.81
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (-) of Neg (nor) Gene_expression (nor) of SP associated with substance p
8) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.79
Dose-response curves for the labeled SP analogs and for unlabeled SP to produce an increase in intracellular Ca++ in CHO cells transfected with the rSPR are shown in Fig. 5.
Positive_regulation (increase) of Gene_expression (produce) of SP associated with substance p
9) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.75
At a concentration of 100 nM, neither Alexa 488-SP nor tetramethylrhodamine-SP inhibited IM; thus they were further tested at a concentration of 1 ?
Positive_regulation (tested) of Neg (nor) Gene_expression (nor) of tetramethylrhodamine-SP associated with substance p
10) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.09 Pain Relevance 0.80
Fluorescein-SP, Alexa 488-SP, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP or tetramethylrhodamine-SP was added at increasing concentrations, from 100 pM to 1 ?
Positive_regulation (increasing) of Gene_expression (added) of tetramethylrhodamine-SP associated with substance p
11) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.58
Statistical analysis showed that there was not a significant difference between the fluorescent conjugates and unlabeled SP when 1 ?
Neg (not) Positive_regulation (was) of Gene_expression (conjugates) of SP associated with substance p
12) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.67
Fluorescein-SP, Alexa 488-SP, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP or tetramethylrhodamine-SP was added at increasing concentrations, from 100 pM to 1 ?
Positive_regulation (increasing) of Gene_expression (added) of SP associated with substance p
13) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.58
Alexa 488-SP produced the most prominent increase in non-specific fluorescence in the absence of cells.
Positive_regulation (increase) of Gene_expression (produced) of SP associated with substance p
14) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.49
On activation with lipopolysaccharide in vitro there was a marked increase in SP expression by mononuclear phagocytes and DCs [13,14,16].
Positive_regulation (increase) of Gene_expression (expression) of SP in mononuclear phagocytes associated with substance p
15) Confidence 0.02 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.13 Pain Relevance 0.67
NGF production in peripheral tissues is enhanced by inflammation, and NGF is taken up and transported in a retrograde manner by nerve fibres to their cell bodies, leading to nerve sprouting and increased expression of TRPV1 and SP.36 Not only does NGF sensitise TRPV1 receptors to protons, enhancing their effect, but it also increases expression of TRPV1.
Positive_regulation (increased) of Gene_expression (expression) of SP in nerve associated with inflammation, nerve growth factor and substance p
16) Confidence 0.01 Published 2008 Journal Gut Section Body Doc Link PMC2564830 Disease Relevance 0.76 Pain Relevance 1.08
Increased numbers of mast cells found in the colonic mucosa of IBD patients are accompanied by dramatically increased expression of TNF-alpha, IL-16, and SP [66].
Positive_regulation (increased) of Gene_expression (expression) of SP in mast cells associated with inflammatory bowel disease and substance p
17) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.98 Pain Relevance 0.25

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