INT121224

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.32
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
bladder 4
neurons 3
Nerve 1
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 55 100.00 Very High Very High Very High
Neuropeptide 1 99.92 Very High Very High Very High
Inflammation 76 99.72 Very High Very High Very High
Lasting pain 3 99.56 Very High Very High Very High
Dorsal horn 1 98.48 Very High Very High Very High
Nerve growth factor 50 98.30 Very High Very High Very High
Spinal cord 8 98.00 Very High Very High Very High
Inflammatory mediators 12 96.80 Very High Very High Very High
cytokine 4 94.60 High High
intrathecal 10 93.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 94 99.72 Very High Very High Very High
Asthma 1 99.58 Very High Very High Very High
Pain 22 99.56 Very High Very High Very High
Disease 7 99.08 Very High Very High Very High
Hypersensitivity 1 98.90 Very High Very High Very High
Neuropathic Pain 50 80.68 Quite High
Cystitis 32 76.08 Quite High
Diabetes Mellitus 46 64.32 Quite High
Emergencies 2 58.76 Quite High
Diabetic Neuropathy 36 56.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons.
Positive_regulation (lead) of in neurons Positive_regulation (induction) of SP in Nerve associated with asthma, nerve growth factor, hypersensitivity, neuropeptide, disease and substance p
1) Confidence 0.14 Published 2004 Journal Clin. Exp. Allergy Section Abstract Doc Link 15347383 Disease Relevance 0.30 Pain Relevance 0.30
Exposure to LPS increased the levels of TNF-alpha, SP and NGF production compared with controls (each p <0.05).
Positive_regulation (increased) of Positive_regulation (increased) of SP
2) Confidence 0.08 Published 2005 Journal J. Urol. Section Body Doc Link 15643278 Disease Relevance 0.15 Pain Relevance 0
The upregulation of SP-positive neurons in our current study is reduced by SB203580, supporting our contention that p38 mediates SP-upregulation in the DRG of db/db mice.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of SP in neurons associated with substance p
3) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.81 Pain Relevance 1.25
Intravesical instillation of SP stimulates NF-kappaB and Nkx-2.5 translocation in the bladder mucosa
Positive_regulation (stimulates) of Positive_regulation (instillation) of SP in bladder associated with substance p
4) Confidence 0.06 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
SP activation of NK1R [3] induces a sequential activation of signaling pathways leading to the production of pro-inflammatory mediators [10,16,17] and pro-inflammatory cytokines such as macrophage migration inhibitory factor (MIF) that plays a major role in bladder inflammation [18].
Positive_regulation (induces) of Positive_regulation (activation) of SP in bladder associated with inflammatory mediators, inflammation, cytokine and substance p
5) Confidence 0.05 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.07 Pain Relevance 0.76

General Comments

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