INT121225

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) plasma membrane (Ntrk1) kinase activity (Ntrk1)
Anatomy Link Frequency
myocyte 2
neurons 2
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 50.00 Quite Low
substance P 2 50.00 Quite Low
qutenza 2 50.00 Quite Low
Central nervous system 14 14.20 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 15 50.00 Quite Low
Heart Rate Under Development 5 47.92 Quite Low
Ganglion Cysts 1 45.04 Quite Low
Dilated Cardiomyopathy 1 23.04 Low Low
Death 7 20.88 Low Low
Disease 101 5.00 Very Low Very Low Very Low
Diabetes Mellitus 50 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 20 5.00 Very Low Very Low Very Low
Cardiovascular Disease 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Based on the extent of SP and trkA co-expression in airway-specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA-mediated SP induction to mediate neurogenic airway inflammation.


Positive_regulation (elevated) of NGF Positive_regulation (activation) of trkA in neurons
1) Confidence 0.49 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
Treatment of co-cultures of sympathetic neurons and cardiac myocytes with NGF, to preferentially activate neuronal TRKA, promotes the release of norepinephrine and increases the myocyte beat rate by fourfold [187].
Positive_regulation (promotes) of NGF Positive_regulation (activate) of TRKA in myocyte
2) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0 Pain Relevance 0

General Comments

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