INT121226

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.70
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
cytosol (Trpv1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
ganglia 2
Ngf (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 11 100.00 Very High Very High Very High
antagonist 32 95.76 Very High Very High Very High
qutenza 106 90.96 High High
Pain 48 90.08 High High
algogenic 5 86.80 High High
Lasting pain 13 86.24 High High
Cancer pain 1 79.40 Quite High
trigeminal ganglion 75 78.48 Quite High
substance P 13 74.48 Quite High
calcitonin gene related peptide 14 73.92 Quite High
Disease Link Frequency Relevance Heat
Pain 61 90.08 High High
Cancer Pain 1 79.40 Quite High
Bone Cancer 1 79.20 Quite High
Ganglion Cysts 106 78.48 Quite High
Nociception 25 67.76 Quite High
Coronary Artery Disease 2 48.72 Quite Low
Osteoarthritis 1 34.48 Quite Low
Neuropathic Pain 6 33.72 Quite Low
Diabetes Mellitus 6 32.24 Quite Low
Peripheral Neuropathy 2 31.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: In the present study, the effect of NGF on tyrosine kinase receptor trkA and the capsaicin receptor TRPV1 expression in airway-specific vagal sensory neurons located in the jugular-nodose ganglia complex (JNC) of mice was investigated.
NGF Spec (investigated) Regulation (effect) of Gene_expression (expression) of TRPV1 in ganglia
1) Confidence 0.62 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
Therefore, blocking NGF action could down regulate TRPV1 expression and function.


NGF Regulation (regulate) of Gene_expression (expression) of TRPV1 associated with nerve growth factor
2) Confidence 0.28 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.40 Pain Relevance 0.77
Chronically-applied NGF differentially modulated P2X3 and TRPV1 receptors
NGF Regulation (modulated) of Gene_expression (receptors) of TRPV1
3) Confidence 0.17 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.30 Pain Relevance 0.66

General Comments

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