INT12123

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Context Info
Confidence 0.03
First Reported 1992
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lynx1)
Anatomy Link Frequency
spinal cord 1
Lynx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 100.00 Very High Very High Very High
spinal-cord stimulation 6 98.92 Very High Very High Very High
agonist 2 97.04 Very High Very High Very High
Spinal cord 1 85.04 High High
Calcitonin gene-related peptide 7 75.00 Quite High
qutenza 2 74.88 Quite High
substance P 1 61.28 Quite High
Inflammation 1 55.88 Quite High
antagonist 1 44.88 Quite Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 88.40 High High
Disease 1 56.56 Quite High
INFLAMMATION 1 55.88 Quite High
Diarrhoea 1 54.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cyclooxygenase inhibitor piroxicam, the neurotoxin tetrodotoxin and the inhibitor of guanylate cyclase, methylene blue, all inhibited the response to both agonists.
Negative_regulation (inhibitor) of neurotoxin tetrodotoxin associated with tetrodotoxin and agonist
1) Confidence 0.03 Published 1993 Journal Free Radic. Res. Commun. Section Abstract Doc Link 8294047 Disease Relevance 0.17 Pain Relevance 0.22
The neurotoxin tetrodotoxin (100 micrograms/kg i.v.) abolished the depressor response to spinal cord stimulation, whereas treatment with propranolol (0.5 mg/kg per minute i.v.), atropine (0.05 mg/kg per minute i.v.), or a combination of pyrilamine (0.5 mg/kg per minute i.v.) and cimetidine (0.5 mg/kg per minute i.v.) did not affect the response.
Negative_regulation (abolished) of neurotoxin tetrodotoxin in spinal cord associated with tetrodotoxin and spinal-cord stimulation
2) Confidence 0.02 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1628392 Disease Relevance 0.15 Pain Relevance 0.57

General Comments

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