INT121239

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.32
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
immune cells 2
motoneurons 2
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 1 98.40 Very High Very High Very High
rheumatoid arthritis 8 96.96 Very High Very High Very High
cytokine 49 86.72 High High
adenocard 3 83.12 Quite High
tolerance 1 76.56 Quite High
agonist 14 75.92 Quite High
Inflammation 101 72.44 Quite High
antagonist 27 55.72 Quite High
Pain 17 50.00 Quite Low
Action potential 2 37.92 Quite Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 17 99.52 Very High Very High Very High
Atherosclerosis 3 98.84 Very High Very High Very High
Systemic Lupus Erythematosus 1 98.16 Very High Very High Very High
Rheumatoid Arthritis 8 96.96 Very High Very High Very High
Disease 20 95.72 Very High Very High Very High
Apoptosis 42 94.40 High High
Alzheimer's Dementia 1 86.04 High High
Amyloid Plaque 1 81.56 Quite High
INFLAMMATION 127 72.44 Quite High
Neurodegenerative Disease 1 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
secretion from immune cells by controlling activation of P2X7.
Regulation (controlling) of Positive_regulation (activation) of P2X7 in immune cells
1) Confidence 0.61 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.33 Pain Relevance 0.07
As a result of the importance of the P2X7R in IL-1?
Regulation (result) of Positive_regulation (importance) of P2X7R
2) Confidence 0.44 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.99 Pain Relevance 0.12
In brainstem slices from 15 to 26 day old pentobarbitone-anesthetized mice, we examined the effect of P2X7RS activation on excitatory postsynaptic currents (EPSCs) recorded from hypoglossal motoneurons using whole-cell patch clamp techniques.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (activation) of P2X7RS in motoneurons associated with medulla
3) Confidence 0.42 Published 2004 Journal Neuroscience Section Abstract Doc Link 15350640 Disease Relevance 0 Pain Relevance 0.13

General Comments

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