INT12124

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 141
Total Number 154
Disease Relevance 82.40
Pain Relevance 25.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 10
chondrocytes 5
arms 3
smooth muscle 2
HPAF-II 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 830 100.00 Very High Very High Very High
metalloproteinase 235 100.00 Very High Very High Very High
chemokine 84 100.00 Very High Very High Very High
Kinase C 9 100.00 Very High Very High Very High
Inflammatory mediators 46 99.84 Very High Very High Very High
bradykinin 1350 99.76 Very High Very High Very High
cINOD 167 99.72 Very High Very High Very High
qutenza 26 99.68 Very High Very High Very High
Enkephalin 31 99.62 Very High Very High Very High
Morphine 20 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 998 100.00 Very High Very High Very High
Adenocarcinoma 529 100.00 Very High Very High Very High
Sprains And Strains 231 100.00 Very High Very High Very High
Targeted Disruption 126 100.00 Very High Very High Very High
INFLAMMATION 1516 99.84 Very High Very High Very High
Chronic Hepatitis 62 99.84 Very High Very High Very High
Stress 2123 99.68 Very High Very High Very High
Thyroid Neoplasm 265 99.68 Very High Very High Very High
Pancreatic Cancer 275 99.52 Very High Very High Very High
Cancer 1132 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Gene_expression (levels) of p40
1) Confidence 0.75 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.29
Apoptosis and cell cycle analysis is carried out by flow cytometry, the phosphorylation of mitogen-activated protein kinases (MAPK) ERK1 and ERK2 is detected by Western blotting assay, and changes of calcium concentration were analyzed using the calcium-sensitive dye Fluo-3 AM.
Gene_expression (detected) of ERK2 associated with apoptosis
2) Confidence 0.73 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.60 Pain Relevance 0.61
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Gene_expression (levels) of ERK2 associated with morphine
3) Confidence 0.72 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.80
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Gene_expression (levels) of ERK associated with morphine
4) Confidence 0.72 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.81
INTERPRETATION: These results demonstrate that multiple sodium channel isoforms (Nav1.3, Nav1.7, and Nav1.8), as well as activated p38 and ERK1/2 MAP kinases, are expressed in painful human neuromas, indicating that these molecules merit study as possible therapeutic targets for the treatment of pain associated with traumatic neuromas.


Gene_expression (expressed) of p38
5) Confidence 0.71 Published 2008 Journal Ann. Neurol. Section Body Doc Link 19107992 Disease Relevance 0.14 Pain Relevance 0
In MCF10A cells, capsaicin did not elicit p38 activation and LC3 conversion and caused the sustained activation of caspase-4.
Gene_expression (activation) of p38 associated with qutenza
6) Confidence 0.66 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.48 Pain Relevance 0.70
Inhibition of the mitogen-activated protein kinase (MAPK) cascade via cytokine suppressive anti-inflammatory drugs, which block p38 MAPK and hence the production of interleukin-1 and tumor necrosis factor-alpha, are most promising new opportunities.
Gene_expression (production) of p38 associated with necrosis, inflammation, cancer, cinod and cytokine
7) Confidence 0.65 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458589 Disease Relevance 1.38 Pain Relevance 0.50
Small molecule inhibitors targeting of p38 MAPK and JNK pathways have been developed and offer a great potential as potent modulators of brain inflammation and gliosis in neurological disorders, where cytokine overproduction contributes to disease progression.
Gene_expression (targeting) of p38 in brain associated with neurological disease, inflammation, encephalitis, gliosis, disease progression and cytokine
8) Confidence 0.65 Published 2009 Journal Anat Rec (Hoboken) Section Abstract Doc Link 19943344 Disease Relevance 1.61 Pain Relevance 0.69
These results suggest that serum levels of p40 IL-12/23 may not be considered as a biologic tool of disease activity assessment in SpA patients.
Gene_expression (/) of p40 associated with disease
9) Confidence 0.65 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.46 Pain Relevance 0.16
Activation of p38 MAPK and the resulting induction of apoptosis in EoL-1 cells may be important to explain the anti-inflammatory action of NSAID in allergic inflammation.
Gene_expression (Activation) of p38 associated with inflammation, hypersensitivity, cinod and apoptosis
10) Confidence 0.64 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 1.14 Pain Relevance 0.53
Moreover, the cell-type and line specific differences in STAT3 and ERK signaling were not due different expression of the signaling proteins as demonstrated by the comparable expression level of total STAT3 and ERK proteins among the cell types (Fig. 1C).


Gene_expression (expression) of ERK
11) Confidence 0.61 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.24 Pain Relevance 0.15
We examined the role of the extracellular signal regulated kinases (ERK) in 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3))-induced gene expression in the differentiated Caco-2 cells. 1,25(OH)(2)D(3)-regulated expression of the 25-hydroxyvitamin D, 24-hydroxylase (CYP24) gene (both natural gene and promoter construct) was strongly modulated by altering ERK activity (i.e., reduced by MEK inhibitors and dominant negative (dn) ERK1 and ERK2, activated by epidermal growth factor) but ERK inhibition had no effect on 1,25(OH)(2)D(3)-regulated expression of the transient receptor potential cation channel, subfamily V, member 6 (TRPV6).
Spec (examined) Gene_expression (role) of ERK in Caco-2 associated with member 8
12) Confidence 0.60 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.08
P40 was absent with the left posterior tibial nerve stimulation.
Neg (absent) Gene_expression (absent) of P40 in posterior
13) Confidence 0.58 Published 1992 Journal Rinsho Shinkeigaku Section Abstract Doc Link 1628436 Disease Relevance 1.45 Pain Relevance 0.30
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Gene_expression (isoforms) of extracellular signal-regulated kinase
14) Confidence 0.57 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Gene_expression (isoforms) of ERK
15) Confidence 0.57 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
To avoid serological crossreactivity with the cellular protein, recombinant p41 proteins from HHV-6A strain GS and HHV-6B strain Z29 were expressed as glutathione-S-transferase fusion proteins (p41-GST), and used as antigens in an enzyme-linked immunosorbent assay (ELISA). p41 variant specific monoclonal antibodies reacted strongly with the respective recombinant proteins.
Gene_expression (expressed) of p41 associated with sprains and strains
16) Confidence 0.57 Published 2002 Journal J. Med. Virol. Section Abstract Doc Link 11793393 Disease Relevance 0.67 Pain Relevance 0.24
To avoid serological crossreactivity with the cellular protein, recombinant p41 proteins from HHV-6A strain GS and HHV-6B strain Z29 were expressed as glutathione-S-transferase fusion proteins (p41-GST), and used as antigens in an enzyme-linked immunosorbent assay (ELISA). p41 variant specific monoclonal antibodies reacted strongly with the respective recombinant proteins.
Gene_expression (expressed) of p41 associated with sprains and strains
17) Confidence 0.57 Published 2002 Journal J. Med. Virol. Section Abstract Doc Link 11793393 Disease Relevance 0.67 Pain Relevance 0.23
In addition, methionine enkephalin also elevates the levels of protein kinase C (PKC) activity and phosphorylated extracellular signal-regulated kinase (ERK) 1/2.
Gene_expression (levels) of extracellular signal-regulated kinase associated with kinase c and enkephalin
18) Confidence 0.56 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.43 Pain Relevance 0.80
In addition, methionine enkephalin also elevates the levels of protein kinase C (PKC) activity and phosphorylated extracellular signal-regulated kinase (ERK) 1/2.
Gene_expression (levels) of ERK associated with kinase c and enkephalin
19) Confidence 0.56 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.43 Pain Relevance 0.80
The activity levels of p38 and JNK were calculated by dividing the intensity of phospho-p38 or phospho-JNK by that of loading control proteins tubulin, actin, or GAPDH, chosen for the best resolution from the kinase bands of interest on the basis of Mr.
Gene_expression (levels) of p38 in bands
20) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0 Pain Relevance 0.07

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