INT121251

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.72
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 92 99.84 Very High Very High Very High
Arthritis 5 99.20 Very High Very High Very High
Dorsal horn 5 95.00 High High
Spinal cord 7 91.28 High High
Inflammatory stimuli 4 88.88 High High
dorsal root ganglion 5 86.00 High High
IPN 1 84.16 Quite High
Neuronal excitability 2 83.84 Quite High
Neuropathic pain 3 75.40 Quite High
Inflammation 39 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 99.64 Very High Very High Very High
Arthritis 5 99.20 Very High Very High Very High
Ganglion Cysts 7 86.00 High High
Neuropathic Pain 11 75.40 Quite High
Hyperalgesia 24 5.00 Very Low Very Low Very Low
Nociception 24 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation suggests that the enhanced Cl- accumulation is not the consequence of transcriptional upregulation of NKCC1 or the downregulation of KCC2 transcription.
Transcription (transcription) of KCC2
1) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.39 Pain Relevance 0.20
We tested for possible effects of the inflammatory mediators on the transcription of NKCC1 and KCC2 by semi-quantitative PCR analysis of the respective mRNAs.
Transcription (transcription) of KCC2 associated with inflammatory mediators
2) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.48 Pain Relevance 0.24
In chronic arthritis, NKCC1 expression remained raised, but KCC2 mRNA and protein expression returned to control levels.
Transcription (expression) of KCC2 associated with arthritis
3) Confidence 0.13 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15350966 Disease Relevance 0.85 Pain Relevance 0.83

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox