INT121274

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.22
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC)
Anatomy Link Frequency
amygdala 1
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 46 100.00 Very High Very High Very High
orphanin 41 100.00 Very High Very High Very High
antagonist 3 99.46 Very High Very High Very High
alcohol 4 99.44 Very High Very High Very High
Hippocampus 4 98.64 Very High Very High Very High
narcan 1 98.50 Very High Very High Very High
amygdala 8 96.96 Very High Very High Very High
agonist 4 89.44 High High
opioid receptor 10 87.16 High High
qutenza 4 84.04 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 98.88 Very High Very High Very High
Recurrence 4 65.16 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Tetraploidy 1 5.00 Very Low Very Low Very Low
Chromosome Duplication 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tertiapin (10 microM), an inhibitor of the inward-rectifier K(+) channels, but not naloxone (0.1 microM), a DOP/KOP/MOP receptor antagonist, prevented the inhibitory effect of nociceptin.
Negative_regulation (effect) of nociceptin associated with orphanin, antagonist and narcan
1) Confidence 0.43 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15351928 Disease Relevance 0 Pain Relevance 0.60
The PNOC/OPRL1 downregulation may underlie impairment of cognitive control over alcohol seeking in alcoholics.
Negative_regulation (downregulation) of PNOC associated with cognitive disorder and alcohol
2) Confidence 0.41 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.10 Pain Relevance 0.53
Reduction in PNOC mRNA (1.7-fold) was found in the hippocampus of alcoholics, whereas OPRL1 mRNA levels were decreased (1.4-fold) in the central amygdala.
Negative_regulation (Reduction) of PNOC in amygdala associated with hippocampus and amygdala
3) Confidence 0.36 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.12 Pain Relevance 0.73
In chicken, PENK and the opioid kappa receptor (OPRK) are located on chromosome 2 and both PNOC and POMC along with the opioid mu receptor (OPRM) are located on chromosome 3.
Negative_regulation (located) of PNOC associated with opioid
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2865548 Disease Relevance 0 Pain Relevance 0.31

General Comments

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