INT1213

Context Info Confidence 0.46 First Reported 1976 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 14 Disease Relevance 4.85 Pain Relevance 2.83

Anatomy Link Frequency RAW 264 4 CSF 2 neural 2 PGE (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 16 98.88 Clonidine 4 98.84 agonist 4 98.62 Inflammatory mediators 4 96.72 Inflammation 117 94.20 Paracetamol 1 92.00 Pain 5 89.56 Analgesic 5 87.56 adenocard 2 85.48 depression 4 84.48

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 34 98.76 Fever 7 98.72 Cancer 130 97.56 INFLAMMATION 124 96.32 Disease 25 90.40 Pain 4 89.56 Intestinal Cancer 9 88.84 Colitis 201 88.32 Body Weight 3 86.48 Pressure And Volume Under Development 4 85.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since expression of both Cox-2 and PGE 2 is increased in the intestinal mucosa of patients with UC, as well as in CAC, Cox-2 induced PGE 2 may be a causal player in complex pathways linking chronic inflammation to the development of CAC [22-26].

Positive_regulation (increased) of Gene_expression (expression) of PGE associated with inflammatory bowel disease, inflammation and cancer

1) Confidence 0.46 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.02 Pain Relevance 0.30

Another group of mice received high dose PGE 2 (200 ?

Positive_regulation (received) of Gene_expression (received) of PGE

2) Confidence 0.40 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.30 Pain Relevance 0

But we do not know if PGE 2 production is necessary and sufficient to promote tumorigenesis in the absence of TLR4.

Positive_regulation (necessary) of Gene_expression (production) of PGE

3) Confidence 0.38 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.05 Pain Relevance 0.08

Our results demonstrated that paeonol inhibited LPS induced expression of NO, PGE(2) and IL-6.

Positive_regulation (induced) of Gene_expression (expression) of PGE

4) Confidence 0.37 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222121 Disease Relevance 0.42 Pain Relevance 0.46

Functional coupling of the inducible enzymes COX-2 and mPGES-1 has been proposed for increased production of PGE(2) in different cell types.

Positive_regulation (increased) of Gene_expression (production) of PGE

5) Confidence 0.34 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.45 Pain Relevance 0.18

LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.

Positive_regulation (resulted) of Gene_expression (production) of PGE in RAW 264

6) Confidence 0.34 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.40 Pain Relevance 0.15

Administration of theophyllin together with endotoxin enhanced the fever reaction and cyclic AMP levels in CSF, but had no influence on stimulation of PGE synthesis.

Positive_regulation (stimulation) of Gene_expression (synthesis) of PGE in CSF associated with fever

7) Confidence 0.23 Published 1976 Journal Pflugers Arch. Section Abstract Doc Link 177944 Disease Relevance 0.35 Pain Relevance 0.17

LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.

Positive_regulation (enhanced) of Gene_expression (production) of PGE in RAW 264

8) Confidence 0.23 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.40 Pain Relevance 0.15

The differentially expressed genes included in these two GO categories are listed in Table 1, together with the genes of the PGE2-synthesizing enzymes PGE synthases and COX-2 for comparison of M-values, fold changes and p values.

Positive_regulation (enzymes) of Gene_expression (synthases) of PGE

9) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.07 Pain Relevance 0

Rauwolscine (1 X 10(-8) and 1 X 10(-7) M) attenuated angiotensin II-induced PGE production and at a higher concentration (1 X 10(-6) M) reduced angiotensin III-induced PGE production.

Positive_regulation (-) of Gene_expression (production) of PGE

10) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.08 Pain Relevance 0.33

Rauwolscine (1 X 10(-8) and 1 X 10(-7) M) attenuated angiotensin II-induced PGE production and at a higher concentration (1 X 10(-6) M) reduced angiotensin III-induced PGE production.

Positive_regulation (induced) of Gene_expression (production) of PGE

11) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.08 Pain Relevance 0.34

Rauwolscine (1 X 10(-8) and 1 X 10(-7) M) attenuated angiotensin II-induced PGE production and at a higher concentration (1 X 10(-6) M) reduced angiotensin III-induced PGE production.

Positive_regulation (induced) of Gene_expression (production) of PGE

12) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.08 Pain Relevance 0.33

The alpha-2 agonist, clonidine, both inhibited the nonadrenergic neural contraction and enhanced PGE synthesis.

Positive_regulation (enhanced) of Gene_expression (synthesis) of PGE in neural associated with agonist and clonidine

13) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.07 Pain Relevance 0.33

The first significant elevation in PGE 2 and LTB 4 levels and MPO activity were observed in stage III.

Positive_regulation (elevation) of Gene_expression (levels) of PGE

14) Confidence 0.03 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15897851 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.